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    Therapeutic protein characterization

    Therapeutic proteins are specially designed for a particular clinical approach. Therapeutic proteins must be extensively characterized to detect molecular variants which can develop naturally or during the manufacturing or storage processes. Any modifications to the protein can impact the therapeutic efficacy and thus they must be closely monitored during development and administration.

    Webinars

    • OCT 14, 2021 | 7:00 AM
      Heterologous Protein Engineering and characterization of native regulatory elements  in E. coli using Massively Parallel CRISPR Editing
      Heterologous Protein Engineering and characterization of native...
      Date: October 14, 2021 Time: 7:00am (PDT), 10:00am (EDT) Heterologous protein expression in model organisms has many applications, including protein engineering, production of industrial enz...
      Speaker: Tyson Shepherd, PhD
      Sponsored By: Inscripta
      22
      OCT 07, 2021 | 11:55 PM
      Examining the Chemotherapeutic Potential of Rosehip Plant Extracts in Triple Negative Breast Cancer
      Examining the Chemotherapeutic Potential of Rosehip Plant Extracts...
      Triple Negative Breast Cancer (TNBC) is an aggressive form of breast cancer, characterized by the characteristic lack of receptors such as human epidermal growth factor receptor-2 (HER-2), t...
      Speaker: Patrick M. Martin, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
      3
      OCT 07, 2021 | 8:00 AM
      SARS-CoV-2 specific B cell detection and therapeutic antibody discovery
      SARS-CoV-2 specific B cell detection and therapeutic antibody...
      Date: October 7, 2021 Time: 8:00am (PDT), 11:00am (EDT) To combat the COVID-19 pandemic, comprehensive characterization of humoral and cellular immune responses to SARS-CoV-2 is essential. A...
      Speaker: Cristina Conforti Andreoni
      Sponsored By: Miltenyi Biotec
      15
      OCT 05, 2021 | 7:00 AM
      Resolving Challenges in Flow Cytometry Panel Design
      Resolving Challenges in Flow Cytometry Panel Design
      Date: October 05, 2021 Time: 7:00am (PDT), 10:00am (EDT) After new users become familiar with flow cytometry instrumentation and learn how to set up the instrument and acquire data, the next...
      Speaker: Michael Kapinsky, PhD , Matthew Goff
      Sponsored By: Beckman Coulter Life Sciences
      13 1
      SEP 22, 2021 | 11:59 PM
      Mechanisms of Podocyte Damage in Alport Syndrome: Insights from the Alport-on-a-chip System
      Mechanisms of Podocyte Damage in Alport Syndrome: Insights from...
      Microtubule plus-end tracking proteins (+TIPs) play key roles in the regulation of microtubule dynamics in vivo. These proteins bind to and regulate microtubule “plus‐ends”, whic...
      Speaker: Astgik Petrosyan, PhD
      Presented at: Cell Biology Virtual Event Series 2021
      0
      AUG 25, 2021 | 7:30 AM
      Keynote Presentation: Development of Pharmacological Chaperones Targeting the Intrinsically Disordered State of Misfolding Proteins in Neurodegenerative Diseases
      Keynote Presentation: Development of Pharmacological Chaperones...
      The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...
      Speaker: Gergely Tóth, PhD, MBA
      Presented at: Neuroscience Virtual Event Series 2021
      6
      AUG 25, 2021 | 12:00 AM
      Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant and How can we Model it?
      Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant...
      Parkinson’s disease (PD) is the second most common neurodegenerative disorder with multiple motor and non-motor symptoms. PD is characterized by the presence on proteinaceous neuronal...
      Speaker: Andrii Domanskyi, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      5
      AUG 25, 2021 | 12:00 AM
      A Novel Mouse Model of Ataxia Telangiectasia for Testing Small Molecule Readthrough (SMRT) Compounds
      A Novel Mouse Model of Ataxia Telangiectasia for Testing Small...
      Ataxia Telangiectasia, also known as A-T, is a devastating neuropediatric and genetic disorder for which there is no cure. Patients suffer from immune deficiency, cancer predisposition, and...
      Speaker: Paul Mathews, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      1
      AUG 24, 2021 | 11:00 AM
      EAD easy as 1-2-3: Making characterization of complex biotherapeutics routine
      EAD easy as 1-2-3: Making characterization of complex biotherapeutics...
      Date: August 24, 2021 Time: 11:00am (PDT), 1:00pm (EDT) Electron-based dissociation mechanisms have shown great promise for advanced characterization of biomolecules. However, routine adopti...
      Speaker: Matt Stone, PhD , Claire Bramwell, PhD
      Sponsored By: Sciex
      9 1
      JUN 02, 2021 | 3:00 PM
      Functional Evaluation of Unique Anti-PDL1 Antibodies Generated through Single Plasma B Cell Cloning on the Beacon® Platform Versus a Standard Hybridoma Approach
      Functional Evaluation of Unique Anti-PDL1 Antibodies Generated...
      PD-L1 is a key inhibitor of T cell activation that is often over-expressed in cancer to escape immune surveillance and promote tumor progression. Blocking antibodies against PD-L1 or its rec...
      Speaker: Neha Yevalekar
      Presented at: Immuno-Oncology Virtual Event Series 2021
      Sponsored By: ChemPartner
      2
      MAY 13, 2021 | 8:00 AM
      Physicochemical Characterization of Antibody-Drug Conjugates
      Physicochemical Characterization of Antibody-Drug Conjugates
      Date: May 13, 2021 Time: 8:00am (PDT), 11:00am (EDT) Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and r...
      Speaker: Shawn Owens, Ph.D. , Jason Lin, Ph.D
      Sponsored By: RedShiftBio
      6 1
      APR 01, 2021 | 8:00 AM
      Develop High Quality Therapeutic Antibodies Straight From Selections in Record Time
      Develop High Quality Therapeutic Antibodies Straight From Selections...
      Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
      Speaker: Andrew Bradbury, MD, PhD , Noah Ditto
      Sponsored By: Carterra
      3 1
      MAR 18, 2021 | 9:00 AM
      Improved Biopharmaceutical Characterization Workflows for Next Generation mAb Based Therapeutics
      Improved Biopharmaceutical Characterization Workflows for Next...
      Date: March 18, 2021 Time: 9:00am (PST), 12:00am (EST) As novel therapeutic modalities progress through development, improved analytical techniques are required to overcome characterization...
      Speaker: Andras Guttman, PhD
      Sponsored By: SCIEX
      4
      FEB 10, 2021 | 8:00 AM
      Unveil the immune response to cancer and infectious disease with powerful immunoassays
      Unveil the immune response to cancer and infectious disease with...
      Date: February 10, 2021 Time: 8:00am (PST), 11:00am (EST) Uncovering the interactions between the immune system and cancer cells or pathogens is key for understanding and controlling both ca...
      Speaker: Sigrun Badrnya, PhD
      Sponsored By: Thermo Fisher Scientific
      14 1
      DEC 10, 2020 | 8:00 AM
      Simple and Fast Charge Variants Analysis of mAbs by CZE
      Simple and Fast Charge Variants Analysis of mAbs by CZE
      Date: December 10, 2020 Time: 8:00am (PST), 11:00am (EST) As you face increasingly shortened timelines to bring new drugs to market, you find yourself strained to finalize analytical methods...
      Speaker: Yan He, Ph.D.
      Sponsored By: SCIEX
      4 1
      DEC 09, 2020 | 7:00 AM
      Characterization of RNA therapeutics from small to large
      Characterization of RNA therapeutics from small to large
      Date: December 9, 2020 Time: 7:00am (PST), 10:00am (EST) In this talk we will discuss the new analytical approaches to characterize RNA molecules from small oligonucleotides to larger messen...
      Speaker: Stephen Lock, PhD
      Sponsored By: SCIEX
      5
      DEC 03, 2020 | 4:30 PM
      An Iterative Approach to Structure-based in silico to in vivo Development of Combinatorial Anti-SARS-CoV-2 Therapy
      An Iterative Approach to Structure-based in silico to in vivo...
      This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
      Speaker: Garth Ehrlich, PhD, FAAAS
      Presented at: Coronavirus Series
      5
      NOV 20, 2020 | 8:00 AM
      Efficiency to Confidence with High Resolution Accurate Mass Spectrometers: Analyzing IGF-1
      Efficiency to Confidence with High Resolution Accurate Mass Spectrometers:...
      DATE: November 20, 2020 TIME: 8am PDT, 11am EDT Insulin-like growth factor-1 (IGF-1) measurement by high-resolution accurate mass-mass spectrometry (HRAM) is replacing IGF-1 immunoassays and...
      Speaker: Tony Maus
      Sponsored By: Thermo Fisher Scientific
      7 1
      NOV 19, 2020 | 9:00 AM
      From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
      From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
      DATE: November 19, 2020 TIME: 9:00am PT, 12am ET Knowledge of the three-dimensional structure of therapeutically relevant targets has become an essential step in the pipeline of drug discove...
      Speaker: Amal Hassan Ali
      Sponsored By: Thermo Fisher Scientific
      16 1
      NOV 19, 2020 | 8:00 AM
      From discovery to functional assays: therapeutic antibody research by Miltenyi Biotec
      From discovery to functional assays: therapeutic antibody research...
      Date: November 19, 2020 Time: 8:00am PST, 11:00am EST Monoclonal antibody-based drugs have shown great potential as a treatment for several cancers. At Miltenyi Biotec, we offer a complete wo...
      Speaker: Dr. Susanne Bethke
      Sponsored By: Miltenyi Biotec
      9
      NOV 12, 2020 | 10:00 AM
      FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
      FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
      Date: November 12, 2020 Time: 10:00am (PST), 1:00pm (EST) Fc receptor based affinity chromatography is a new emerging field of Fc functionality analytics. FcRn affinity columns separate anti...
      Speaker: Tilman Schlothauer, Ph.D
      Sponsored By: Roche CustomBiotech
      3
      NOV 12, 2020 | 12:00 AM
      Principles of Effective Method Development in Pathobiology Research
      Principles of Effective Method Development in Pathobiology Research
      Immunohistochemistry (IHC) is used to determine spatial relationships where we can identify the localization of target proteins in specific regions and cells of a tissue. IHC has been the go...
      Speaker: Vivian Barry, MS
      Presented at: DISCOVERY Global User Symposium
      2
      OCT 21, 2020 | 12:00 AM
      Developing a Complete Workflow Including N-Linked Glycans Analysis for Monoclonal Antibodies with High Resolution Mass Spectrometry and Fluorescence Detection
      Developing a Complete Workflow Including N-Linked Glycans Analysis...
      Accurate characterization of monoclonal antibodies is essential to development of biotherapeutics. Thorough understanding of biotherapeutic properties aids in the optimization of bioprocess...
      Speaker: Brian Domanski
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 08, 2020 | 10:30 AM
      Keynote Presentation: Principles of Effective Method Development in Pathobiology Research.
      Keynote Presentation: Principles of Effective Method Development...
      Immunohistochemistry (IHC) is used to determine spatial relationships where we can identify the localization of target proteins in specific regions and cells of a tissue. IHC has been the go...
      Speaker: Vivian Barry, MS
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      Sponsored By: Roche Diagnostics
      1
    OCT 14, 2021 | 7:00 AM
    Heterologous Protein Engineering and characterization of native regulatory elements  in E. coli using Massively Parallel CRISPR Editing
    Heterologous Protein Engineering and characterization of native...
    Date: October 14, 2021 Time: 7:00am (PDT), 10:00am (EDT) Heterologous protein expression in model organisms has many applications, including protein engineering, production of industrial enz...
    Speaker: Tyson Shepherd, PhD
    Sponsored By: Inscripta
    22
    OCT 07, 2021 | 11:55 PM
    Examining the Chemotherapeutic Potential of Rosehip Plant Extracts in Triple Negative Breast Cancer
    Examining the Chemotherapeutic Potential of Rosehip Plant Extracts...
    Triple Negative Breast Cancer (TNBC) is an aggressive form of breast cancer, characterized by the characteristic lack of receptors such as human epidermal growth factor receptor-2 (HER-2), t...
    Speaker: Patrick M. Martin, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
    3
    OCT 07, 2021 | 8:00 AM
    SARS-CoV-2 specific B cell detection and therapeutic antibody discovery
    SARS-CoV-2 specific B cell detection and therapeutic antibody...
    Date: October 7, 2021 Time: 8:00am (PDT), 11:00am (EDT) To combat the COVID-19 pandemic, comprehensive characterization of humoral and cellular immune responses to SARS-CoV-2 is essential. A...
    Speaker: Cristina Conforti Andreoni
    Sponsored By: Miltenyi Biotec
    15
    OCT 05, 2021 | 7:00 AM
    Resolving Challenges in Flow Cytometry Panel Design
    Resolving Challenges in Flow Cytometry Panel Design
    Date: October 05, 2021 Time: 7:00am (PDT), 10:00am (EDT) After new users become familiar with flow cytometry instrumentation and learn how to set up the instrument and acquire data, the next...
    Speaker: Michael Kapinsky, PhD , Matthew Goff
    Sponsored By: Beckman Coulter Life Sciences
    13 1
    SEP 22, 2021 | 11:59 PM
    Mechanisms of Podocyte Damage in Alport Syndrome: Insights from the Alport-on-a-chip System
    Mechanisms of Podocyte Damage in Alport Syndrome: Insights from...
    Microtubule plus-end tracking proteins (+TIPs) play key roles in the regulation of microtubule dynamics in vivo. These proteins bind to and regulate microtubule “plus‐ends”, whic...
    Speaker: Astgik Petrosyan, PhD
    Presented at: Cell Biology Virtual Event Series 2021
    0
     
     
  • AUG 25, 2021 | 7:30 AM
    Keynote Presentation: Development of Pharmacological Chaperones Targeting the Intrinsically Disordered State of Misfolding Proteins in Neurodegenerative Diseases
    Keynote Presentation: Development of Pharmacological Chaperones...
    The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...
    Speaker: Gergely Tóth, PhD, MBA
    Presented at: Neuroscience Virtual Event Series 2021
    6
    AUG 25, 2021 | 12:00 AM
    Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant and How can we Model it?
    Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant...
    Parkinson’s disease (PD) is the second most common neurodegenerative disorder with multiple motor and non-motor symptoms. PD is characterized by the presence on proteinaceous neuronal...
    Speaker: Andrii Domanskyi, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    5
    AUG 25, 2021 | 12:00 AM
    A Novel Mouse Model of Ataxia Telangiectasia for Testing Small Molecule Readthrough (SMRT) Compounds
    A Novel Mouse Model of Ataxia Telangiectasia for Testing Small...
    Ataxia Telangiectasia, also known as A-T, is a devastating neuropediatric and genetic disorder for which there is no cure. Patients suffer from immune deficiency, cancer predisposition, and...
    Speaker: Paul Mathews, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    1
    AUG 24, 2021 | 11:00 AM
    EAD easy as 1-2-3: Making characterization of complex biotherapeutics routine
    EAD easy as 1-2-3: Making characterization of complex biotherapeutics...
    Date: August 24, 2021 Time: 11:00am (PDT), 1:00pm (EDT) Electron-based dissociation mechanisms have shown great promise for advanced characterization of biomolecules. However, routine adopti...
    Speaker: Matt Stone, PhD , Claire Bramwell, PhD
    Sponsored By: Sciex
    9 1
    JUN 02, 2021 | 3:00 PM
    Functional Evaluation of Unique Anti-PDL1 Antibodies Generated through Single Plasma B Cell Cloning on the Beacon® Platform Versus a Standard Hybridoma Approach
    Functional Evaluation of Unique Anti-PDL1 Antibodies Generated...
    PD-L1 is a key inhibitor of T cell activation that is often over-expressed in cancer to escape immune surveillance and promote tumor progression. Blocking antibodies against PD-L1 or its rec...
    Speaker: Neha Yevalekar
    Presented at: Immuno-Oncology Virtual Event Series 2021
    Sponsored By: ChemPartner
    2
     
     
  • MAY 13, 2021 | 8:00 AM
    Physicochemical Characterization of Antibody-Drug Conjugates
    Physicochemical Characterization of Antibody-Drug Conjugates
    Date: May 13, 2021 Time: 8:00am (PDT), 11:00am (EDT) Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and r...
    Speaker: Shawn Owens, Ph.D. , Jason Lin, Ph.D
    Sponsored By: RedShiftBio
    6 1
    APR 01, 2021 | 8:00 AM
    Develop High Quality Therapeutic Antibodies Straight From Selections in Record Time
    Develop High Quality Therapeutic Antibodies Straight From Selections...
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    Speaker: Andrew Bradbury, MD, PhD , Noah Ditto
    Sponsored By: Carterra
    3 1
    MAR 18, 2021 | 9:00 AM
    Improved Biopharmaceutical Characterization Workflows for Next Generation mAb Based Therapeutics
    Improved Biopharmaceutical Characterization Workflows for Next...
    Date: March 18, 2021 Time: 9:00am (PST), 12:00am (EST) As novel therapeutic modalities progress through development, improved analytical techniques are required to overcome characterization...
    Speaker: Andras Guttman, PhD
    Sponsored By: SCIEX
    4
    FEB 10, 2021 | 8:00 AM
    Unveil the immune response to cancer and infectious disease with powerful immunoassays
    Unveil the immune response to cancer and infectious disease with...
    Date: February 10, 2021 Time: 8:00am (PST), 11:00am (EST) Uncovering the interactions between the immune system and cancer cells or pathogens is key for understanding and controlling both ca...
    Speaker: Sigrun Badrnya, PhD
    Sponsored By: Thermo Fisher Scientific
    14 1
    DEC 10, 2020 | 8:00 AM
    Simple and Fast Charge Variants Analysis of mAbs by CZE
    Simple and Fast Charge Variants Analysis of mAbs by CZE
    Date: December 10, 2020 Time: 8:00am (PST), 11:00am (EST) As you face increasingly shortened timelines to bring new drugs to market, you find yourself strained to finalize analytical methods...
    Speaker: Yan He, Ph.D.
    Sponsored By: SCIEX
    4 1
     
     
  • DEC 09, 2020 | 7:00 AM
    Characterization of RNA therapeutics from small to large
    Characterization of RNA therapeutics from small to large
    Date: December 9, 2020 Time: 7:00am (PST), 10:00am (EST) In this talk we will discuss the new analytical approaches to characterize RNA molecules from small oligonucleotides to larger messen...
    Speaker: Stephen Lock, PhD
    Sponsored By: SCIEX
    5
    DEC 03, 2020 | 4:30 PM
    An Iterative Approach to Structure-based in silico to in vivo Development of Combinatorial Anti-SARS-CoV-2 Therapy
    An Iterative Approach to Structure-based in silico to in vivo...
    This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
    Speaker: Garth Ehrlich, PhD, FAAAS
    Presented at: Coronavirus Series
    5
    NOV 20, 2020 | 8:00 AM
    Efficiency to Confidence with High Resolution Accurate Mass Spectrometers: Analyzing IGF-1
    Efficiency to Confidence with High Resolution Accurate Mass Spectrometers:...
    DATE: November 20, 2020 TIME: 8am PDT, 11am EDT Insulin-like growth factor-1 (IGF-1) measurement by high-resolution accurate mass-mass spectrometry (HRAM) is replacing IGF-1 immunoassays and...
    Speaker: Tony Maus
    Sponsored By: Thermo Fisher Scientific
    7 1
    NOV 19, 2020 | 9:00 AM
    From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
    From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
    DATE: November 19, 2020 TIME: 9:00am PT, 12am ET Knowledge of the three-dimensional structure of therapeutically relevant targets has become an essential step in the pipeline of drug discove...
    Speaker: Amal Hassan Ali
    Sponsored By: Thermo Fisher Scientific
    16 1
    NOV 19, 2020 | 8:00 AM
    From discovery to functional assays: therapeutic antibody research by Miltenyi Biotec
    From discovery to functional assays: therapeutic antibody research...
    Date: November 19, 2020 Time: 8:00am PST, 11:00am EST Monoclonal antibody-based drugs have shown great potential as a treatment for several cancers. At Miltenyi Biotec, we offer a complete wo...
    Speaker: Dr. Susanne Bethke
    Sponsored By: Miltenyi Biotec
    9
     
     
  • NOV 12, 2020 | 10:00 AM
    FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
    FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
    Date: November 12, 2020 Time: 10:00am (PST), 1:00pm (EST) Fc receptor based affinity chromatography is a new emerging field of Fc functionality analytics. FcRn affinity columns separate anti...
    Speaker: Tilman Schlothauer, Ph.D
    Sponsored By: Roche CustomBiotech
    3
    NOV 12, 2020 | 12:00 AM
    Principles of Effective Method Development in Pathobiology Research
    Principles of Effective Method Development in Pathobiology Research
    Immunohistochemistry (IHC) is used to determine spatial relationships where we can identify the localization of target proteins in specific regions and cells of a tissue. IHC has been the go...
    Speaker: Vivian Barry, MS
    Presented at: DISCOVERY Global User Symposium
    2
    OCT 21, 2020 | 12:00 AM
    Developing a Complete Workflow Including N-Linked Glycans Analysis for Monoclonal Antibodies with High Resolution Mass Spectrometry and Fluorescence Detection
    Developing a Complete Workflow Including N-Linked Glycans Analysis...
    Accurate characterization of monoclonal antibodies is essential to development of biotherapeutics. Thorough understanding of biotherapeutic properties aids in the optimization of bioprocess...
    Speaker: Brian Domanski
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
    OCT 08, 2020 | 10:30 AM
    Keynote Presentation: Principles of Effective Method Development in Pathobiology Research.
    Keynote Presentation: Principles of Effective Method Development...
    Immunohistochemistry (IHC) is used to determine spatial relationships where we can identify the localization of target proteins in specific regions and cells of a tissue. IHC has been the go...
    Speaker: Vivian Barry, MS
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    Sponsored By: Roche Diagnostics
    1
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