Assistant Professor, Department of Pharmaceutics and Pharmaceutical Chemistry, Adjunct Assistant Professor, University of Utah
BIOGRAPHY
Speakers
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Jason Lin, Ph.D
Senior Field Application Scientist, RedShiftBioBIOGRAPHY
Event Date & Time
Date: May 13, 2021
Time: 8:00am (PDT), 11:00am (EDT)
Abstract
Antibodies are the most rapidly growing form of biotherapeutics. High-throughput methods of characterization are essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen discusses advanced characterization techniques to assess biophysical properties of antibody-drug conjugates (ADCs). For ADCs, the level of payload and site of conjugation are determined using LC/MS. Thermal stability and binding affinity are characterized using DSC, IR, and ITC. These methods, along with MMS, can be used for the in-depth analysis of these biologics and for routine product validation.
Learning Objectives
- Analyze the Higher Order Structure (HOS) of therapeutic antibodies and antibody drug conjugates.
- Explain the effects in secondary structure of conjugated proteins.
- Demonstrate the AQS3pro, with Microfluidic Modulation Spectroscopy, provides a reliable increased sensitive and higher resolution for secondary structure analysis of biotherapeutics.
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LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.
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