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Current methods used to predict safety and efficacy of candidate drugs accounts for as much as 90% failure rate. Approximately 30% of drugs have failed......
Cancer is a group of complex genomic diseases. Today still most clinicians, patients ans policymakers think that precision oncology is the sequencing of cancer genomes, which is for many pati...
The global incidence of cancer is on a steady rise, with a projected annual diagnosis rate of nearly 30 million cases by 2040. Despite this alarming trend, our understanding of the intricate...
The capture of tumor-derived extracellular vesicles (TEVs) by cells in the tumor microenvironment (TME) contributes to metastasis and notably to the formation of the pre-metastatic niche (PM...
In recent years in vivo CNS dosing has gone from being a relatively uncommon modality to one that is fairly standard. However, bringing this administration route into maturity requires an un...
Healthy human red blood cells (RBCs) gradually degrade over their lifespan of ~120 days. However, sickle cells - RBCs from sickle cell disease (SCD) patients - degrade much faster within the...
Acute T-cell mediated rejection (TCMR) is the most frequent complication after liver transplantation (LT), which can affect up to 50% of LT recipients in the first 5-year post-transplant. Li...
Current clinical methods used to identify epithelial ovarian cancer are often too late – when the cancer is at an advanced stage, leaving the patient with limited therapeutic options....
Success stories in the field of cell therapies are making headlines on a daily basis. These achievements involve complex manufacturing processes in which cytokines play a key role. Choosing...
In vitro ADME and drug-drug interaction (DDI) investigations are early activities in the drug development process that are critical for framing downstream decision making. Understanding the...
Wastewater-based surveillance is valuable as it allows for the detection of pathogens before symptomatic cases are identified. In Korea, wastewater surveillance has been implemented, and the...
Millions of people around the world are sickened or killed due to food or waterborne pathogens. The efficiency of sample processing, testing, analyst......
In the United States, over 40,000 transplantations are performed annually. Ensuring post-transplant success requires diligent monitoring of infectious diseases that are associated with a wid...
In this webinar, Victoria Quiett of Thermo Fisher Scientific will dive into a comprehensive look at key components of running Pharmacogenomics (PGx) in your lab. The webinar will discuss the...
Clinical laboratories generate most of the objective data on which diagnostic, preventive, and therapeutic decisions are made. By considering the current availability of information analytic...
Small extracellular vesicles (EVs) and Exosomes released by cells, have gained significant interest in biomedical research due to their potential applications in diagnostics and therapeutics...
Flow cytometry plays a crucial role in the rapidly growing field of cell therapy, this method is used to identify different types of cells throughout the manufacturing process, from initial...
Recent developments in mass spectrometry-based single-cell proteomics (SCP) have resulted in dramatically improved sensitivity, yet the relatively low measurement throughput remains a limita...
Liquid biopsy is an emerging area of clinical research, particularly in the context of cancer. As a minimally invasive complementary or alternative approach to tissue biopsies, liquid biopsi...
Quantitative mass spectrometry-based proteomic experiments are designed to answer increasingly complex questions. For example, we may want to characterize changes in protein abundance in bio...
CRISPR-based forward genetic screens can be used to identify essential genes in proliferating human cell lines. Although environmental factors also influence gene essentiality, most CRISPR-b...
Isobaric labeling enables the multiplexed analysis of up to 18 proteomes or PTMomes in a single analysis and provides information on protein and peptide abundance across all samples simultan...
Functional interactions between cytotoxic immune cells and tumor cells are central to anti-cancer immunity. Some of the proteins involved, particularly immune checkpoints expressed by T cell...
As the demand for renewal fuel feedstocks continues to grow, non-food feedstocks production must significantly increase to meet demand. Winter oilseeds grown in cooler climates provide oppor...
Webinar airing too early or too late for you? This webinar will also be available: September 13 at 10:00am PDT, 1:00pm EDT https://www.labroots.com/ms/webinar/dpcr-liquidbiopsy-panel-2 and S...
Liquid biopsy is an emerging area of clinical research, particularly in the context of cancer. As a minimally invasive complementary or alternative approach to tissue biopsies, liquid biopsi...