Senior Director of Computational Technologies
BIOGRAPHY
Date: October 24, 2023 Time: 9:00am PDT, 11:00am CDT, 12:00pm EDT
Introducing a streamlined solution to capture superior multiomic information at single-base resolution from limited DNA
Speakers
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Nick Harding, Ph.D.
Data Scientist-BioinformaticsBIOGRAPHY
Event Date & Time
Date: October 24, 2023
Time: 9:00am PDT, 11:00am CDT, 12:00pm EDT
Abstract
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology in health and disease. The interaction of genetics with the epigenome plays a causal role in cell fate, ageing, and disease development. For example, modified cytosine profiles of cancer are differential from non-cancer, and genetic plus modified cytosine data together are more powerful for the detection of early cancer than either alone.
Methods widely used to detect epigenetic DNA bases do not distinguish unmodified cytosines and thymine, therefore fail to capture common C-to-T mutations and thus capture incomplete genetic information. As a result, studies of genetics and methylation together require separate measurements of genetics and epigenetics, which present multiple challenges and complexities.
We introduce duet multiomics solution +modC, a single base-resolution sequencing methodology that sequences complete genetics and cytosine modifications in a single workflow, enabling the identification of genetic variants and quantification of modified cytosine levels in a single experiment, at high accuracy for both genetics and epigenetics.
During this webinar, we will discuss:
1. Getting complete information from your liquid biopsy
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How to generate high-quality genomic and epigenomic data from a single blood draw
2. Allele-specific methylation: how genetic variance and epigenetics converge
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Novel solutions unlock a new level of understanding
3. Introducing duet multiomics solution +modC: superior mutiomic data from a single workflow
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