Protein nanoparticles have better biocompatibilities and biodegradability and also have the possibilities for surface modifications. These nanostructures can be synthesized by using proteins like albumin, gelatin, whey protein, gliadin, legumin, elastin, zein, soy protein, and milk protein.
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Determining the purity of LNPs loaded with nucleic acids can be challenging due to their size heterogeneity. Here, we present analytical ultracentrifugation (AUC) methods that use multiwavel...
AAVs and LNPs are complementary gene transfer systems with respect to immunogenicity, tissue tropism and types of nucleic acids, which can be delivered. AUC provides a wealth of orthogonal a...
Date: January 25, 2023 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CET) The field of proteomics is poised for a single-molecule revolution – enabling more comprehensive analysis of the...
Since its discovery in late 2019 the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a global pandemic of coronavirus disease 2019 (COVID-19). As of July of 2022, mo...
Date: November 17, 2021 Time: 1:00am (PST), 9 am BST, 10 am CEST The growing list of nanoparticle payloads and carrier systems includes proteins, lipids, polymers, small molecules, and more,...
Cas9 based therapeutics have the potential to revolutionize the treatment of genetic diseases. However, safe and effective methods for delivering Cas9 protein, gRNA and donor DNA need to be...
Date: May 13, 2021 Time: 8:00am (PDT), 11:00am (EDT) Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and r...
Platform based therapeutics and vaccines offer a unique opportunity to simplify and streamline the drug development process. Moderna has taken the approach of harnessing the power of mRNA as...
Date: February 11, 2021 Time: 8:00am (PST), 11:00am (EST) Getting answers on what’s in your precious AAV, LVV, or lipid nanoparticle (LNP) sample means wanting to use the lowest possib...
Ice formation is a global issue that poses serious challenges for many applications. Certain species in colder regions of the world have adapted to that climate by producing antifreeze (glyc...
DATE: October 15, 2020 TIME: 8am PDT, 11am EDT Density gradient centrifugation is an effective method for the isolation and purification of small particles. Hollow rotors capable of hosting...
Cas9 based therapeutics have the potential to revolutionize the treatment of genetic diseases. However, safe and effective methods for delivering Cas9 protein, gRNA and donor DNA need to be...