Monoclonal proteins, also called M proteins, are elevated in the blood and urine of patients with multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS), a condition which is highly correlated to bone marrow and blood cancers. Monoclonal proteins are antibodies produced in the bone marrow by the cancerous cells.
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Most FDA-approved therapeutic drugs target transmembrane proteins, yet the development of monoclonal antibodies for multi-transmembrane protein targets has been limited. Despite the abundanc...
There is a great variability in testing for monoclonal gammopathies. During his presentation, Dr. David F. Keren, MD, Clinical Professor of Pathology at University of Michigan Health, descri...
Date: April 13, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) It is important to confirm the sequences and post-translational modifications (PTMs) of protein therapeutics to ensure d...
FEB 22, 2023 | 10:30 AM
C.E. CREDITS
Immunogens with native conformation and a high-throughput IgG cloning platform are two of the most important key components for high quality lead antibody molecules discovery. DIMABIO’...
FEB 09, 2023 | 9:00 AM
C.E. CREDITS
Date: February 09, 2023 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CET) Monoclonal gammopathies (MGs) comprise a broad set of diseases involving the abnormal clonal proliferation of plasma c...
Date: June 22, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Rabbits have a robust and unique immune system that enables the generated antibodies with superior specificity, affinity,...
Date: June 01, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) The manufacturing process for cell and gene therapies is complex and can contain process-related impurities from multiple...
There is growing interest in the development of integrated continuous bioprocesses for the production of important biotherapeutics due to the potential for enhanced productivity, greater fle...
In the last decades, the upstream processing in biopharma industry has been revolutionized regarding the production of bioactive materials such as monoclonal antibodies, proteins and biother...
Date: March 1, 2022 Time: 9:00am (PST), 12:00pm (EST) Dr. David F Keren currently serves as a Professor of Pathology at the University of Michigan (Michigan Medicine). Dr. Keren received his...
Cancer is a leading cause of morbidity and mortality in developed countries including the United States. Early detection of various cancers, before they spread and become incurable, has been...