High-throughput, high resolution purity and heterogeneity characterization of biologics using breakthrough multi-capillary technology

Over the last 20 years, automated capillary electrophoresis (CE) has become an industry-preferred technique for quantitative purity and heterogeneity characterization of a variety of biotherapeutics, including monoclonal antibodies, antibody derivatives, peptides, oligonucleotides, vaccines and cell and gene therapy modalities. Innovations such as the development of a replaceable sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) separation matrix, capillary isoelectric focusing (cIEF) workflows and high-resolution glycan CE separations have emerged as key workflows. These workflows enable highly reproducible and portable multi-attribute analysis of therapeutic quality. Over time, however, new challenges around sample throughput and workflow complexity have appeared, requiring processing of a growing number of molecules in clinical pipelines while delivering critical results more efficiently.

 

In this webinar, we take a detailed look at a new system developed by SCIEX to help address these challenges. The BioPhase 8800 system is a parallel separation CE platform that uses a multi-capillary approach to accelerate analytical throughput, which has the potential to drastically minimize product development time. This system incorporates novel technical features, including a precision-manufactured, liquid-cooled multi-capillary cartridge along with integrated UV/LIF detection, 96-well plate compatibility and on-board sample storage. Additionally, the system provides simplicity through the incorporation of intuitive method development software and touchscreen instrument control, placing system monitoring at the user’s fingertips. The BioPhase 8800 system represents an evolution in CE technology, providing innovative, intuitive workflows while maintaining industry-leading assay accuracy and precision to help you accelerate your biologic drug development.

 

Learning Objectives