MilliporeSigma is the U.S. life science business of Merck KGaA, Darmstadt, Germany, a leading science and technology company in healthcare, life science and performance materials. Our life science focus areas include advanced laboratory water purification,...
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MilliporeSigma is the U.S. life science business of Merck KGaA, Darmstadt, Germany, a leading science and technology company in healthcare, life science and performance materials. Our life science focus areas include advanced laboratory water purification, filtration, chromatography, chemistry, CRISPR gene editing, antibody technologies, cell biology, DNA & RNA oligos, biomarker detection, live cell analysis, environmental monitoring, and support for clinical, diagnostic, and pharmaceutical development and manufacturing. Find our broad portfolio of 300,000 products, an expansive global footprint and an industry-leading eCommerce platform at SigmaAldrich.com.
With the promise of targeted gene editing and CRISPR technologies comes increasing experimental complexity and design challenges. Success in gene editing experiments may depend on many varia...
Due to the complexity of cannabis product matrices, sample preparation for cannabinoid testing is very challenging. Accurate extraction and analysis......
RNA interference (RNAi) offers a fast and easy system to study gene functions. However, the traditionally used small interfering RNAs (siRNAs) can exhibit pronounced and problematic off-targ...
Date: September 28, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) CRISPR/Cas gene editing technology has rapidly evolved over the last decade. Its versatility extends from creating t...
Thin-Layer Chromatography (TLC) and High-Performance Thin-Layer Chromatography (HPTLC) are convenient, fast, and efficient separation techniques for analytical methods without demanding comp...
In this webinar, we will be discussing some of our most recent testing using our Cas9 proteins, Cas9 RNP nickases in a variety of human cell types, including primary T-cells. Cas nucleases wh...
Real-time PCR, or quantitative qPCR, is a commonly used molecular biology lab technique to determine the actual amount of PCR product at a given cycle. For quantitative reverse transcription...
In this webinar, we will discuss our most recent additions to our CRISPR protein portfolio, the GFP-SpCas9 and GFP-eCas9 fusion proteins. The two GFP-Cas9 fusion proteins offer great visualiz...
Antibodies are extremely valuable and ubiquitous tools in life science research, but in spite of their widespread use in immunoassays over the past several decades, there is still a lack of u...
High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance. Millipor...
Monitoring protein biomarkers in cerebrospinal fluid (CSF) of patients with Alzheimer’s Disease (AD) has been highly beneficial to understanding disease progression. While several...
CRISPR Cas9 nucleases have revolutionized gene editing enabling unprecedented efficiency of targeted mutagenesis. Even with such powerful technology at hand, sophisticated projects, su...
Natural killer cells (NKs) are lymphocytes of the innate immune system that target and kill cancer cells through the secretion of lytic granules containing granzyme B and perforin. This proce...