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In the last years, progress has been made regarding the differentiation of human pluripotent stem cells into neural stem cells and astrocytes, growing into neurospheres and cerebral organoids...
A fundamental question in neuronal development is how growth cone cytoskeletal dynamics are coordinated to promote accurate axonal navigation. To address this question, we focus on microtubul...
Our laboratory uses tools from pharmacology, genomics, and cell signaling to identify new precision anticancer therapeutic strategies. Under this broad heading, our work involves three key a...
We currently do not have effective vaccines or antiviral drugs for most of the viral diseases that afflict humans. Antiviral therapies that enable long-term control over human immunodeficien...
Einstein researcher Robert Singer, Ph.D., discusses a breakthrough in microscopy that is allowing scientists to track messenger RNA in living cells in real time. The study, published in the S...
The attractiveness of 3D printing technology in the microfluidic field is growing, specifically stereolithographic (SLA) type 3D printers, owing to their low cost, versatility, fast and easy...
Proteins are the functional blocks of any biological entity from 50 nm sized viruses to the 100 ft long mammals (blue whale). They perform intra cellular, tissue, organ, system, or organism...
Genome engineers can leverage an ever-expanding array of biological and computational tools to make targeted genetic changes. Maintaining and optimizing components ranging from reagent desig...
As millions of people all over the world get their genome sequenced, physicians and researchers as well as the individuals themselves will want to ask questions of these data. To ask question...
New generations of treatments successfully target cancer cell signaling and modulate anti-cancer immunity to improve outcomes for advanced-stage malignancies. Such clinical responses are gove...
Setting up an analytical laboratory requires a clear objective and analytical resources, both instrumentation and technical. The four main areas of focus exist during this process: 1) Instru...
In this study, we evaluated the concordance of targeted sequencing results between paired ctDNA and tumor samples from early breast cancers scheduled for curative surgery with or without adj...
Over the past 6 years, a number of agents, all mechanistically different, have been approved with a statistically significant survival benefit as monotherapy for treatment of metastatic castr...
Quantification of cellular growth before and after an experiment is an essential technique for cell-based studies. Listen in as our scientific expert, Miriam Ferrer, Ph.D., reviews methods to...
The continuous generation of blood cells throughout life relies on the existence of hematopoietic stem cells (HSC) generated during embryogenesis. Given the importance of HSC transplantation...
Nucleic acid testing is crucial for the prevention, diagnosis and treatment monitoring of many diseases in medicine. Over the last years, microRNAs (miRNAs), short non-coding RNAs, as biomar...
Many computational approaches exist for predicting the effects of amino acid substitutions from protein sequence. These are often (incorrectly) used for judging disease predisposition from in...
The cannabis industry as a whole is under considerable scrutiny. Finger-pointing and blame regarding inaccurate product labels run rampant. Media outlets have often faulted the sk...
Immune escape mechanisms such as the induction/recruitment of immunosuppressive cells and the increased expression of various immunosuppressive molecules including PD-1/PD-1 ligands are esse...
The scale-up and characterization of industrial bioprocesses is to a large extent still based on empirical knowledge. With advanced algorithms and graphic processing units in the computation...
The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
The last decade has seen a significant shift in the way that mammalian cells are used in biomedical science. Researchers are increasingly turning from simple, reductionist recombinant cells t...
Endometrial cancer is the most common gynecologic malignancy in the United States and both the incidence and associated mortality are rising. When detected early, endometrial cancer survival...
Mitochondrial defects represent a common pathogenetic mechanism associated with neurodegeneration. At the same time, mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases...