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Neoantigens are peptides derived from patient-specific and tumor-specific mutations, which can be recognized by the immune system and mediate tumor recognition that leads to immune destructi...
The tumor-associated microbiota is an inherent component of the tumor microenvironment across various human cancer types1. Although members of tumor-associated microbiomes can be identified...
The elegant and well-orchestrated molecular players responsible for normal neurodevelopment harbor the capacity for detrimental repercussions if mis-expressed at the wrong time, or in the wr...
Over the past 10 years, we have come to a greater understanding of the pathogenesis of men who succumb to prostate cancer. One critical aspect is the role of molecular drivers in patients wi...
Conventional imaging studies such as ultrasound, computed tomography, and magnetic resonance imaging are increasingly detecting small renal masses, which are interpreted by radiologists as h...
Effective cellular therapies for solid tumors remain elusive. Advances in gene editing and synthetic biology offer great potential for improving the safety and functionality of engineered ce...
Natural killer (NK) cells, immune cells with an innate ability to recognize and eliminate cancer cells, have emerged as attractive effectors in immunotherapy, owing in large part to their ab...
Informed consent (IC) is a fundamental aspect of ethical clinical research, safeguarding the rights and well-being of participants. It empowers participants with comprehensive information ab...
As the opioid epidemic continues to claim lives and devastate families across the nation and world, we recognize September 21, 2023 as opioid awareness day. Opioids are analgesics with high...
Preanalytical errors and unsuitable samples can account for up to 70% of lab errors. 1 These errors can be attributed to improper specimen collection, specimen transportation, and specimen p...
In clinical laboratory settings, tests for coagulation factors are regularly run to test for inherited or acquired deficiencies in patients suspected of ongoing bleeding risk. Available test...
Extracellular vesicles (EVs) are lipid-bilayer enclosed nano-sized vesicles that are released by all cell types and found in all bodily fluids. EVs are emerging as important regulators of bo...
Current methods used to predict safety and efficacy of candidate drugs accounts for as much as 90% failure rate. Approximately 30% of drugs have failed......
The global incidence of cancer is on a steady rise, with a projected annual diagnosis rate of nearly 30 million cases by 2040. Despite this alarming trend, our understanding of the intricate...
The capture of tumor-derived extracellular vesicles (TEVs) by cells in the tumor microenvironment (TME) contributes to metastasis and notably to the formation of the pre-metastatic niche (PM...
In recent years in vivo CNS dosing has gone from being a relatively uncommon modality to one that is fairly standard. However, bringing this administration route into maturity requires an un...
Healthy human red blood cells (RBCs) gradually degrade over their lifespan of ~120 days. However, sickle cells - RBCs from sickle cell disease (SCD) patients - degrade much faster within the...
Acute T-cell mediated rejection (TCMR) is the most frequent complication after liver transplantation (LT), which can affect up to 50% of LT recipients in the first 5-year post-transplant. Li...
Current clinical methods used to identify epithelial ovarian cancer are often too late – when the cancer is at an advanced stage, leaving the patient with limited therapeutic options....
Success stories in the field of cell therapies are making headlines on a daily basis. These achievements involve complex manufacturing processes in which cytokines play a key role. Choosing...
In the United States, over 40,000 transplantations are performed annually. Ensuring post-transplant success requires diligent monitoring of infectious diseases that are associated with a wid...
Clinical laboratories generate most of the objective data on which diagnostic, preventive, and therapeutic decisions are made. By considering the current availability of information analytic...
Small extracellular vesicles (EVs) and Exosomes released by cells, have gained significant interest in biomedical research due to their potential applications in diagnostics and therapeutics...
Efficient protein turnover is essential for cell homeostasis and organ function. Loss of proteostasis is a hallmark of aging, which culminates as a severe reduction in protein turnover rates...
RNA viruses use a variety of interactions with host proteins to gain entry, to evade immune responses, to promote viral replication, and to promote viral egress and spread. These interaction...
Recombinant cytokines and growth factors are essential components for cell culture. Since they are so widely used, it is worth taking a closer look at them and understand their characteristi...
Neoantigens are peptides derived from patient-specific and tumor-specific mutations, which can be recognized by the immune system and mediate tumor recognition that leads to immune destructi...
