Molecular Neuroscience: is a division of neuroscience that examines concepts in molecular biology applied to the nervous systems of animals. As with molecular biology, molecular neuroscience is a relatively new field that is considerably dynamic.
Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
Date: April 11, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Duchenne muscular dystrophy is caused by mutations in the dystrophin encoding DMD gene that disrupt the reading frame. M...
Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
Date: November 8, 2022 Time: 1:00pm (SGT), 12:00pm (EST), 6:00am (CET) Antibodies are vital tools in many of the laboratory techniques that are used...
Date: October 04, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) The ability to derive induced pluripotent stem cells (iPSCs) from differentiated cell types such as fibroblasts, has r...
Date: July 19, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Cryo-EM is rapidly becoming the method of choice for structural biologists and biochemists around the world, helping thes...
Date: July 14, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Sensory perception is modulated in a top-down fashion by higher brain regions to regulate behavioral responses. In olfact...
Date: March 31, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CET) Formalin-fixed paraffin-embedded (FFPE) tissues are the most widely used clinical sample types in histology and molecular...
Date: March 23, 2021 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEDT) In this presentation, Dr. Middleton will review the development and deployment of large-scale saliva-based COVID-19 test...
NanoString has started an ambitious project called the "Spatial Organ Atlas." The goal of this initiative is to map the architecture of tissues with spatially resolved whole transc...
Date: February 24, 2021 Time: 9:00am (PST), 12:00pm (EST) Cytokine profiling is a valuable tool used in preclinical research for monitoring an immune response and cell signaling pathways dur...
Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
Date: October 14, 2021 Time: 9:00am (PDT), 12:00pm (EDT), 5:00pm GMT Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring spe...
Date: October 13, 2021 Time: 7:00am (PDT), 10:00am (EDT) Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring specific target...
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
In this preliminary experiment, we used spatial transcriptomics to assess the gene expression profiles of microglia or astrocytes in relation to their distance from plaques. We compared 18-m...
Technological advances such as single-cell RNA sequencing accelerated our understanding of cellular diversity in tissues. However, the ability to elucidate this cellular heterogeneity while...
In 1910, Harrison published the first report of frog embryonic sympathetic ganglia grown in hanging drops of lymph for a few days, where single neurons extended nerve fibers with complex gro...
Emerging data from several expansive clinical trials indicates that common chronic vascular risk factors such as diabetes, hypertension, obesity, and age increase the risk of stroke and deme...
The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...
Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
Date: April 11, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Duchenne muscular dystrophy is caused by mutations in the dystrophin encoding DMD gene that disrupt the reading frame. M...
Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
Date: November 8, 2022 Time: 1:00pm (SGT), 12:00pm (EST), 6:00am (CET) Antibodies are vital tools in many of the laboratory techniques that are used...
Date: October 04, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) The ability to derive induced pluripotent stem cells (iPSCs) from differentiated cell types such as fibroblasts, has r...
Date: July 19, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Cryo-EM is rapidly becoming the method of choice for structural biologists and biochemists around the world, helping thes...
Date: July 14, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Sensory perception is modulated in a top-down fashion by higher brain regions to regulate behavioral responses. In olfact...
Date: March 31, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CET) Formalin-fixed paraffin-embedded (FFPE) tissues are the most widely used clinical sample types in histology and molecular...
Date: March 23, 2021 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEDT) In this presentation, Dr. Middleton will review the development and deployment of large-scale saliva-based COVID-19 test...
NanoString has started an ambitious project called the "Spatial Organ Atlas." The goal of this initiative is to map the architecture of tissues with spatially resolved whole transc...
Date: February 24, 2021 Time: 9:00am (PST), 12:00pm (EST) Cytokine profiling is a valuable tool used in preclinical research for monitoring an immune response and cell signaling pathways dur...
Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
Date: October 14, 2021 Time: 9:00am (PDT), 12:00pm (EDT), 5:00pm GMT Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring spe...
Date: October 13, 2021 Time: 7:00am (PDT), 10:00am (EDT) Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring specific target...
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
In this preliminary experiment, we used spatial transcriptomics to assess the gene expression profiles of microglia or astrocytes in relation to their distance from plaques. We compared 18-m...
Technological advances such as single-cell RNA sequencing accelerated our understanding of cellular diversity in tissues. However, the ability to elucidate this cellular heterogeneity while...
In 1910, Harrison published the first report of frog embryonic sympathetic ganglia grown in hanging drops of lymph for a few days, where single neurons extended nerve fibers with complex gro...
Emerging data from several expansive clinical trials indicates that common chronic vascular risk factors such as diabetes, hypertension, obesity, and age increase the risk of stroke and deme...
The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...