Cofilin 1 (5) Alexa Fluor® 680 | Santa Cruz Biotechnology
mouse monoclonal IgG2b; Cofilin 1 Antibody (5) is an IgG2b κ mouse monoclonal Cofilin 1 antibody (also designated Cofilin antibody, or CFL1 antibody) that detects the Cofilin 1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Cofilin 1 Antibody (5) is available as both the non-conjugated anti-Cofilin 1 antibody, and multiple Alexa Fluor® conjugates. Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally-associated Actin subunits, changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK-1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F-Actin.
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