Stay informed on developments in cancer and oncology diagnosis, prevention and treatment through these curated webinars. As the race toward a cure for cancer continues, advances in cancer research are constantly revealed as innovation in the field of oncology progresses.
Variation in gene expression among cell types, tissues, and organisms is commonly examined by reverse transcription quantitative PCR, or RT-qPCR. In this process, RNA is isolated from sample...
The future of cancer care is contingent on better understanding of molecular, clinical, and outcome data. This can be achieved by leveraging collaborative affiliations and networks locally a...
Single-cell RNA sequencing (scRNA-seq) is an important technology that reveals gene expression differences between different cell types. Yet scRNA-seq data can be challenging to analyze and...
Bromodomains (BRDs) are evolutionarily conserved protein domains that interact with acetylated histones and set off a chain of events that includes recruiting transcription factors and other...
In real-world evidence (RWE), temporal shifts in clinical knowledge and practice need to be adjusted for treatment effect assessment. We use electronic health records (EHR) data to 1) assess...
Breast cancer is the number one cause of cancer in women. Although many risk factors for breast cancer have been identified, only some are modifiable. Since 2004, incidence rates have been r...
Gene regulatory networks are representations of the relationship between transcription factors and their target genes. By modeling gene regulatory networks, it is possible to identify change...
Mathematical methods can be used to study evolutionary processes associated with carcinogenesis. Selection, mutation, and drift all play a role in cancer dynamics and cancer treatment. I wil...
Successful cancer patient advocacy has many components. Patients and survivors are in the best position to tell their stories and advocate for better care and treatment. However, with few su...
Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, but is often hampered by low expression...
Learning Objectives: 1. Classify the obstacles to successful manufacturing of antigen-specific T-cells in immunotherapy. 2. Highlight the effects of CD45RA+ subsets in expansion of antigen-s...
Learning Objectives 1. Identify 3 obstacles that inhibit the immune cell response to cancer. 2. List 3 aspects of T cells antitumor function that can be improved with costimulatory signals....
Date: October 05, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Cancer is a complex disease at the level of both cells and tissues, and uncovering novel treatments requires understan...
The microenvironment of many solid tumors impedes many immunotherapeutic treatments by inhibiting the effector functions of many classes of anti-tumor immune cells, including effector T cell...
Antibody-based cancer therapies have clear advantages over chemotherapeutic drugs thanks to their high specificity and low risk of side effects. However, it can be difficult to identify targ...
The ultimate promise of tumor immunotherapy is dependent on the generation of effective immunity against cancer, including CD4 and CD8 T cell responses. However, activating T cells in cancer...
Human solid tumors, like breast cancers, represent a heterogeneous group of diseases that is best demonstrated through many differences in clinical outcomes within homogenously treated patie...
Molecular diagnostic tests are currently used for infectious disease testing due to the superior sensitivity and specificity that can be obtained. Due to the success that has been obtained w...
Tumors invade surrounding tissue as cancer progresses, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their interactions has hampered mechanistic ins...
Individuals with Lynch syndrome (LS) are prone to develop early-onset mismatch repair deficient (dMMR) colorectal- and endometrial cancers due to germline pathogenic variants (PVs) in one of...
The majority of disease-associated genetic variants are thought to have regulatory effects, including disruption of transcription factor (TF) binding and alteration of downstream gene expres...
We recently determined that concurrent inhibition of autophagy, using the lysosomal inhibitor chloroquine (CQ), and of ERK, using a small molecule ERK inhibitor (ERKi), synergistically suppr...
There are known outcome disparities between Black and White patients with pancreatic neuroendocrine tumors (pNETs). Multiple retrospective series have found that Black patients have more adv...
The increasing quantity and quality of spatially resolved omics data provide a unique opportunity to explore the complex molecular mechanisms that take place in biological systems. However,...
Artificial Intelligence (AI) is a computer program designed to perform operations typical of human intelligence, such as self-learning. AI is taking over different fields in science; we alre...
Prostate cancer (PCa) affects one in nine men and is the most diagnosed solid tumor cancer among men in the United States. The introduction of the prostate-specific antigen (PSA) biomarker b...