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Gene regulatory networks are representations of the relationship between transcription factors and their target genes. By modeling gene regulatory networks, it is possible to identify change...
Mild traumatic brain injuries (mTBIs) are a prevalent health issue in North America. There is increasing pressure to utilize ecologically valid models of closed-head mTBI in the preclinical...
G Protein Coupled Receptors (GPCRs) are therapeutic targets for many medications used to treat a variety of disease states. A large number of genetic variants have been identified in the gen...
Learning Objectives: 1. Discover how Genetics is not the major determinant of chronic diseases and cancers; human microbiome and nutrition heavily contribute to their onset and progression....
The global incidence of cancer is on a steady rise, with a projected annual diagnosis rate of nearly 30 million cases by 2040. Despite this alarming trend, our understanding of the intricate...
Learn about how the new Ion Torrent Genexus System is addressing key challenges to next-generation sequencing (NGS) implementation, like hands-on time, time-to-result, user expertise, and af...
Lipids are important effector molecules, however current methodologies are not sufficient for global lipidomic profiling in biological systems. Learn how new innovations using Orbitrap Tribr...
The majority of disease-associated genetic variants are thought to have regulatory effects, including disruption of transcription factor (TF) binding and alteration of downstream gene expres...
B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
T-cells targeting shared oncogenic mutations can induce durable tumor regression in epithelial cancer patients. Such T cells can be detected in tumor-infiltrating lymphocytes and peripheral...
Cancer, as a disease, starts with a change in the genome that results in the downregulation of genes involved in "normal" cell behavior. This genetic change can either be induced b...
At Biogen Idec, we have implemented a 3 part innovation operating model which includes innovation mentoring, agile experimentation and transition of experiments into pilots. In this presenta...
Allenes, compounds containing two double bonds across three contiguous carbons, are versatile synthetic intermediates due to their substituent loading capacity and ability to generate one or...
In the next five years, the majority of clinical diagnostic labs competing to offer NGS oncology testing will be performing comprehensive genomic profiling (CGP). Yet scaling to CGP introduc...
In recent years substance-related overdoses, many of which involve opioids, have contributed to more deaths than car accidents. Opioid Use Disorder (OUD) is a medical condition that continue...
We started our experience with prostate cancer in 2002 with primitive robotic platforms. Our main goal was to provide an alternative to open and laparoscopic surgery....
High production ability has been used for primary selection in dairy breeding schemes. In particular, milk yield, fat yield, and protein yield are the most important economic traits for dair...
Preclinical research and development are the cornerstone of modern drug discovery. A variety of biological systems including in vitro, 3D cultures, and organoids are essential tools, with ul...
Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
The analysis of oligonucleotide and mRNA therapeutics requires robust and accurate analytical characterization to confirm identity, and to determine purity and quality....
Silk is essential to the life histories of more than 800,000 species across the arthropod tree of life. Humans have harnessed the ability of a handful of these for use in the sericulture ind...
Actin cytoskeleton is essential for eukaryotic cells. To exert its countless cellular functions, actin undergoes dynamic remodeling orchestrated by the large number of actin-interacting fact...
Mass spectrometry-based proteomics is a powerful technique for the analyses of thousands of proteins, fueling biomarker research and drug discovery. With the rich complex data from each prec...
Get to know Luminex’s xMAP® Technology all over again. For 27 years, xMAP Technology has become known as the worldwide leader in bead-based multiplexing. With the new xMAP INTELLIF...