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In the United States, cancer disproportionately impacts Black and African American individuals. Identifying genetic factors underlying cancer disparities has been an important research focus...
How organisms control organ size is a fundamental question in developmental and regenerative biology. The underlaying mechanisms are not well defined. For instance, we don’t fully unde...
High grade serous ovarian cancer is characterized by genomic instability, with ~50% of advanced tumors harboring homologous recombination repair (HRR) pathway deficiency (HRD). HRD results i...
Technological advances in Artificial Intelligence (AI), particularly deep learning, have demonstrated remarkable progress in image-recognition tasks. Methods ranging from convolutional neura...
Come join us for a live chat with Bernd Bodenmiller. When you enter the meeting room you can raise your hand to be unmuted by our moderator to ask your questions or just introduce yourself a...
Capturing membrane proteins in their native membrane nanodomain contexts Kallol Gupta, Ph.D. The intricate molecular environment of the native membrane profoundly influences every aspect of...
Genome Engineering allows the easy manipulation of genomes down to the nucleotide level. CRISPR is a revolutionizing tool for generating custom edited cell and pre-clinical animal models for...
As we further understand the complexity and diversity of cellular states, it is becoming necessary for a cellular engineering toolbox, consisting of molecular tools that allow control over c...
Traumatic brain injury (TBI) is a widespread global health concern, impacting approximately 10 million individuals annually. Beyond the initial acute phase, TBI often results in enduring neu...
Most bladder cancer (BC) cases are non-muscle-invasive BC (NIBMC), which is rarely lethal. However, nearly one-fifth of NMIBC cases progress to muscle-invasive BC (MIBC), which shows a 5-yea...
Health economists are great at calculating a value-based price for diagnostic tests. Given the unexpected supply and demand for SARS-CoV-2 tests during the pandemic, efficient allocation of...
The microenvironment of many solid tumors impedes many immunotherapeutic treatments by inhibiting the effector functions of many classes of anti-tumor immune cells, including effector T cell...
The disposition of antibody-based therapeutics is generally determined by both target-mediated and non-target processes, the latter being an often-overlooked aspect. Target-independent liabi...
Learning Objectives: 1. Define the impact of PD-L1 expressed on non-tumor, non-hematopoietic cells in T cell-mediated tumor control 2. Reveal the contribution of IFNg signaling in dermal lym...
NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
Over the past 25 years, Luminex’s xMAP® Technology has emerged as the worldwide leader in bead-based multiplexing. The new xMAP® INTELLIFLEX platform combines the proven perfor...
The ultimate promise of tumor immunotherapy is dependent on the generation of effective immunity against cancer, including CD4 and CD8 T cell responses. However, activating T cells in cancer...
Immune cell therapies hold tremendous potential in the treatment of cancer. Among immune cells, natural killer (NK) cells have a powerful innate ability to recognize and eliminate tumor cell...
Interested in learning more about assay design for primers and probes? Join us for this special Guardian of Your Science “Ask the Expert” webinar, hosted by field applications sc...
Cells in their natural environment are surrounded by a complex extracellular matrix that provides structure and functional cues to the surrounding cells. Hydrogels can be used to approximate...
Traditional methods for pathogen detection are often expensive and time-consuming and requires a well-equipped laboratory. Here we present a low-cost, deployable paper-based biosensor device...
Black Americans have an increased risk for age-related cognitive decline and Alzheimer's disease (AD) compared to other ethnic and racialized groups. However, risk factors for age-relate...
The Irvine CubeSat STEM Program (ICSP) is a collaboration between Irvine Public Schools Foundation, and Irvine and Tustin Unified school districts that provides teams of students from all si...