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Intestinal epithelial cells lining the surface of our gastro-intestinal tract form a tight monolayer which serves as the primary barrier separating us from the luminal content of the gut. Th...
Brain malignancies can either originate from within the CNS (gliomas) or invade from other locations in the body (metastases). A highly immunosuppressive tumor microenvironment (TME) influen...
Advanced therapy medicinal products (ATMPs) are ‘living drugs’ that have proven highly effective at treating diseases, such as cancer, that were once thought untreatable. As &lsq...
Traditional hybridoma and phage display methods have failed to yield therapeutic antibodies against difficult targets like most GPCRs and ion channels. This presentation will introduce Berke...
T cells exquisitely discriminate between antigenic and self-peptide ligands presented on major histocompatibility complexes (pMHCs) despite subtle differences in affinities. This aspect of a...
Learning Objectives: 1. Classify the obstacles to successful manufacturing of antigen-specific T-cells in immunotherapy. 2. Highlight the effects of CD45RA+ subsets in expansion of antigen-s...
Ninety percent of therapeutic agents reaching clinical trial fail to reach entry to market, with safety concerns being a major cause for failures in phase I and II clinical trials. Drug-indu...
We have harnessed homologous recombination to modify the genome of human stem cells with high frequencies (>40%). By designing the recombination donor in different ways, we can achieve a...
Borrelia burgdorferi, the causative agent of Lyme disease, cycles between an Ixodes spp. vector and a vertebrate reservoir host, typically small rodents. Humans become infected when they int...
High volume clinical MS proteomic evaluation of plasma samples enriched for exosomes offering a real-time and non-invasive perspective of changing maternal and fetal tissues....
Long-read sequencing was declared the method of the year for 2022 and, indeed, has fully arrived on the computational biology scene. Specifically, Oxford Nanopore Sequencing technology has e...
As the use of engineered cells for the production of numerous research and clinical applications increases, the need to monitor multiple markers representing the stability and quality of the...
Simple and sensitive nucleic acid-based molecular detection plays a crucial role in the early diagnosis of infectious diseases and the rapid screening of cancers. CRISPR technology has recen...
Accurate prediction of anticancer drug efficacy on each patient’s cancer before the initiation of therapy has the potential to significantly reduce the treatment burden and enhance cli...
The regions of our genome responsible for encoding the genes that regulate our immune response are some of the most complex and polymorphic known. This complexity encompasses multiple types...
The study of target-focused, disease relevant biology for drug discovery requires a comprehensive suite of tools that allow multiple aspects of the biology to be assessed. Thermo Fisher...
The application of modeling tools to better understand and control bioprocess development and manufacturing has become a hot topic within the last few years. However, what do we actually nee...
This presentation will discuss some of the challenges related to developing antibody therapeutics and how GenScript's comprehensive portfolio of services and products can increase the ef...
The World Alzheimer's Report estimates that ~50M people live with dementia, of which Alzheimer's disease (AD) represents approximately 60-80% of all cases. Early diagnosis is imperat...
Chimeric antigen receptor (CAR) T cells have demonstrated significant success in treating relapsed or treatment-refractory hematologic malignancies in the clinic, inducing remissions in 70-9...
Environmental monitoring in a food manufacturing environment includes viable air sampling as well as surface sampling. Viable air sampling measures organisms in the air and surface sampling...