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We recently determined that concurrent inhibition of autophagy, using the lysosomal inhibitor chloroquine (CQ), and of ERK, using a small molecule ERK inhibitor (ERKi), synergistically suppr...
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a novel virus that causes COVID-19 and has considerable variability in clinical outcomes among infected patients. The GENCOV stu...
Novel immunotherapy has revolutionized the landscape of cancer therapy in multiple tumor types since Ipilimumab, the first ICB agent, was approved for the treatment of metastatic melanoma is...
Human skin is characterized by a limited number of phyla including, Actinomycetota, Bacillota and Pseudomonadota. In particular, Staphylococcus (Bacillota) and Corynebacterium (Actinomycetot...
Adjuvant discovery is largely devoted toward the development of vaccines meant to elicit prophylactic humoral immunity. While useful against infectious diseases, this mode of adaptive immuni...
Understanding morphogenesis is an inherently four-dimensional problem, as cells change position in space and the embryo is transformed over time. Dorsal intercalation of epidermal cells in t...
The field of gene therapy has enabled the treatment and potential cures for serious, monogenetic diseases. This form of advanced therapy relies on the delivery of the “correct” c...
Experience the Revolution of DNA Polymerase Technology: Choosing the Best DNA Polymerase for Efficient PCR Workflows. PCR has revolutionized modern molecular biology, but its success would n...
Current methods used to predict safety and efficacy of candidate drugs accounts for as much as 90% failure rate. Approximately 30% of drugs have failed......
For centuries, humans have become infected with endemic circulating Coronaviruses (hCoV), typically repeatedly throughout life. To understand how these respiratory infections establish CD4 T...
Racial and ethnic minorities often experience cancer disparities in the United States with higher disease prevalence, shorter survival, and higher death rates with many cancer types. These d...
Molecular testing of NCSLC biopsies is extremely important in the care and management of these patients. However, NCSLC biopsies are typically very small and require multiple types of analys...
Immunohistochemistry (IHC) has been an indispensable tool for daily pathology practice. Multiplex designs have further facilitated its utility with improved efficacy. Several techniques of m...
This webinar is designed to explore the fundamental characteristics of reverse transcriptases and the essential factors that play a pivotal role in achieving high-quality cDNA synthesis from...
Myeloid neoplasms are a group of heterogeneus disorders originating from the neoplastic transformation of a pluripotent hematopoietic progenitor cell. Following the acquisition of somatic mu...
Microfluidic technologies have opened up new possibilities for ultra-low volume, and ultrafast assays, compared to bulk-scale counterparts. We have been focused on developing new tools for d...
Coronavirus research cannot wait. As we know researchers around the world are diligently working to gain a better understanding of the novel coronavirus with the goal of rapidly identifying...
Summary: Cancer neoantigens are highly specific to the tumor, potently immunogenic and can be targeted by both vaccines and engineered cellular therapies. This talk will introduce the defini...
One of the central tenants of biology is that our genetics—our genotype—influences the physical characteristics we manifest—our phenotype. But with more than 25,000 human g...
The quest to decipher the complex molecular events underpinning cell polarity and organelle segregation during eukaryotic cell division presents a formidable challenge. A predominant focus o...
The recent outbreak of SARS-CoV-2 underscores the need for understanding the evolutionary processes that drive the emergence and adaptation of zoonotic viruses in humans. Here, we show that...
Laboratory plastics are critical to scientific research, but these plastics often have a high environmental impact. Analysis shows that a large portion......
Cannabis laboratory employee turnover is common, extraordinarily expensive, time consuming, and risks harming internal culture. Surprisingly, most cannabis laboratories are unaware of an ext...
Anthropogenic microparticles, including microplastics, are commonly found in nearshore environments, where they may be entrained in coastal waters, sequestered in sediments, or ingested by a...
Though AsCas12a fills a crucial gap in the current genome editing toolbox, it exhibits relatively poor editing efficiency, restricting its overall utility. In collaboration with Integrated D...