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Microtubules (MTs) are dynamic cytoskeleton polymers forming a polarized intracellular network that provides structural support, facilitates intracellular transport and drives chromosome seg...
Natural killer (NK) cells, immune cells with an innate ability to recognize and eliminate cancer cells, have emerged as attractive effectors in immunotherapy, owing in large part to their ab...
Lessons around leveraging high-complexity next-generation sequencing tests for precision infectious disease discovery to guide patient treatment and improve health outcomes. Learning Objecti...
The objective of this randomized, blinded controlled trial was to evaluate the safety and relative effects of different formulations containing Cannabidiol (CBD) and melatonin, with and with...
For more than a century, breakthroughs in biological sciences have relied on the ability to study cells outside of respective organisms. While majority of cell culturing is still performed u...
Though tumor targeting using chimeric receptors (CAR) engineered to bind tumor-associated surface proteins such as CD19 in B cells have demonstrated remarkable efficacy in cancer, this thera...
This presentation will describe two microfluidic techniques that my research group has developed for single-cell manipulation and analysis. The first is called Digital microfluidic Isolation...
Shantanu will be providing an overview about how predictive genomics is a powerful capability to help predict disease risk and understand drug response in order to improve health outcomes an...
Inflammatory myopathies are a group of rare diseases that are characterized by progressive muscle weakness due to chronic skeletal muscle inflammation. Classification of these rare diseases...
Multi-target screening can offer great insight into the genetic pathways in drug resistance and disease. RNAi and the fast pace of CRISPR technology development has brought sophisticated opt...
Despite the immense promise of cancer immunotherapies, significant challenges have been mounting to overcome treatment resistance and to improve efficacy. Strategies such as the combination...
Many current technologies used in drug discovery and preclinical development programmes typically involve multi-step operations, extensive hands-on time, and lengthy liquid handling processe...
Selective vulnerability of brain regions and specific neural populations in neurodegeneration remains little understood. We hypothesize that pre-existing physiological differences in neurons...
Allogenic cell therapies require the constant supply of billions of cells generated by robust, and economically viable bioprocesses. Human induced pluripotent stem cells (iPSCs) are a unique...
Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
The inner nuclear membrane of eukaryotic cells defines many aspects of gene expression and chromatin organization. It is also therapeutically important as several diseases, termed “lam...
The Genome in a Bottle Consortium has published benchmarks for variant calling, but some challenging medically-relevant genes have been partially or fully excluded due to mapping challenges,...
Aflatoxins are carcinogenic mycotoxins that have adverse health effects on both humans and animals consuming contaminated food and feed, respectively. A method has been developed for the hig...
Join this year's poster presenters in the Poster Hall during the Poster Networking Hour, Wednesday, November 1st, from 10:00 AM –11:00 AM PDT , to chat live about their posters and...
Genomic profiling in various cancers has become standard of care today. Dr. Chandra will discuss the challenges and opportunities of precision oncology testing in community practice and...
Immunotherapy such as immune checkpoint inhibitor antibodies have revolutionized the treatments for hard-to-treat cancers, with durable responses observed in clinics. However, the overall re...
Extracellular vesicles (EV) from many cell types have demonstrated therapeutic potential against many different diseases. Inhibiting progress in this area is the capability to produce EVs in...
Saliva serves as a reservoir for the upper aerodigestive tract (UADT). Saliva collection is non-invasive, convenient, and amenable to self-collection. Thus, saliva is an ideal resource for l...
Learning Objectives: 1. Describe and discuss some of the unique aspect of in vivo studies. 2. Identify specific study practices to ensure high quality study data and animal welfare. 3. Discu...