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The assessment of pigmented lesions is a difficult area of dermatology and dermatopathology. Melanoma is the leading cause of cancer in woman age 25-29 years, yet it is also a leading c...
The Tumor Microenvironment (TME) is a highly complex niche, with many different cell types characterized by a range of biomarkers. Clever staining protocols like Cycle Immunofluorescence, an...
Copy number variant (CNV) analysis has been part of clinical diagnostics for almost two decades. With the evolution of genomic technologies for CNV detection, we have learned that CNVs can r...
The Human Gene Mutation Database (HGMD) is a one-of-a-kind resource containing data for hundreds of thousands of variants within the context of associated phenotype(s). Specifically, HGMD pr...
Tumors invade surrounding tissue as cancer progresses, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their interactions has hampered mechanistic ins...
The CYP2D6 enzyme metabolizes approximately 25% of commonly used pharmaceuticals and is of intense pharmacogenetic interest. Polymorphisms in CYP2D6 can alter an individual’s response...
Cancer is a heterogeneous but related group of diseases wherein cells in certain tissues of the body proliferate uncontrollably and eventually invade adjacent and distant tissues. The oldest...
Motor coordination relies on accurate predictions that specify how the body should move in particular sensorimotor contexts. Although such predictions are thought to be stored as associative...
Heterotetrameric adaptor protein (AP) complexes play key roles in protein sorting and transport vesicle formation in the endomembrane system of eukaryotic cells. One of these complexes, AP-4...
Substance use disorder (SUD) remains a highly stigmatized medical condition in the US. One of the most effective methods of treatment for SUD, specifically for opioid use disorder and alcoho...
From data to insight: Explore the full potential of high dimensional data by leveraging machine learning algorithms 1:30–2:00 pm PDT Presented By: Qianjun Zhang, MS Utilizing FCS Expre...
November 13, 2020 4:00 PM PST | November 14, 2020 8:00 AM SGT
Three-dimensional (3D) cell culture spheroids and aggregates are preferred over monolayer cell culture due to their architectural and functional similarity to solid tumors. To study expressi...
After a brief definition of terms (what are bioplastics?), this lecture will discuss various material and application examples for biobased and/or biodegradable plastics. An overview on the...
Prostate cancers are considered immunologically ‘cold’ tumors given the very few patients who respond to checkpoint inhibitor therapy (CPI). Recently, enrichment of interferon st...
Ribonucleic acid (RNA) has a breathtaking variety of biological functions, which far exceeds its classical role as a carrier of genetic information. The repertoire of this versatile molecule...
Coronavirus Immunotherapeutic Consortium (CoVIC) is an international effort to conduct side-by-side, apples-to-apples comparisons of leading therapeutic antibody candidates against the SARS-...
Accurate prediction of CYP2D6 activity from genotype data is of utmost importance as CYP2D6 pharmacogenetic (PGx) testing is increasingly used to guide drug therapy. However, given the compl...
Learning Objectives: 1. Define applications of approved and experimental (multiplexing IF) biomarker assessment in Immuno-Oncology 2. Define bottlenecks and areas of improvement to current t...
Innate and adaptive immunity mechanisms provide antiviral protection in mammals. In this talk, I shall present recent findings from my lab and collaborators revealing a distinct form of mamm...
Advancements in immuno-oncology have been moving at an ever-quickening pace. From the development of new CAR-T therapies to a better understanding of the mechanism of action of monoclonal an...
Single-cell RNA sequencing (scRNA-seq) is an important technology that reveals gene expression differences between different cell types. Yet scRNA-seq data can be challenging to analyze and...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
Current drug discovery workflows rely on the synthesis and bioactivity assessment of large compound libraries, both processes which heavily depend on high-throughput (HT) experimentation to...
Children efficiently develop their visual systems through learning from their environment. How this development unfolds in noisy real-world data streams remains largely unknown. Deep neural...
An overview of the Arrowhead Forensics products that are used from the crime scene to the Forensic Laboratories such as Toxicology/Serology and DNA Labs....
We present a novel workflow for native MS, using a robust and sensitive LC/MS method using standard LC flow for native protein analysis. Most of the native MS analyses are using a nano-elect...