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We work in the framework of the Human Induced Pluripotent Stem Cells Initiative (HipSci) project, funded by the Wellcome Trust and MRC. We provide a dedicated laboratory space for collaborati...
Buerger’s disease, commonly known as Thromboangiitis obliterans, is a non-atherosclerotic, segmental inflammatory disease that can affect the small and medium-sized arteries of young pe...
Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
PacBio Sequencing has been recognized as the gold standard in microbial sequencing due to simultaneously providing long sequence reads (genome contiguity), high consensus accuracy (genome acc...
The discovery of the CRISPR/Cas9 system has transformed research and now allows straightforward alterations in the genome and can be exploited to introduce changes to mimic diseases. This pre...
Background and aim: Multiplexing of biomarker panels by microsphere-based technologies are robust and cost-effective methods. The QuantiGene™ Plex Assay (ThermoFisher Scientific) platf...
AOAC approvals benefit the cannabis industry by providing you third party independent validation to authenticate package insert claims and the test kit performance providing confidence and b...
The field of melanoma has been transformed by the parallel development of effective immune and targeted therapies. There is now strong evidence of cross-talk between oncogenic signaling...
Cannabis use, both recreational and as medicine is proliferating worldwide. It's reasonable to ask why people are using cannabis and who are appropriate candidates for cannabis therapy. T...
Tumors are often categorized into standard molecular subtypes. However, largescale studies have demonstrated that patient heterogeneity in the regulatory make-up of tumors remain. At the tran...
The agricultural sector has been through significant changes since the 2018 Farm Bill was enacted. Hemp production was legalized at the federal level in the United States. Hemp production an...
More than half of the states around the country have legalized marijuana laws that permit individuals to use marijuana for medical or recreational purposes. However, the possession and...
Point-of-care testing (POCT) allows for prompt clinical interventions by returning fast and reliable results near patients. This important role in patient management has led to the widespread...
Over the past 25 years many advances in techniques have been incorporated into infectious disease research. From genetically modified animals to advances in basic techniques that improve res...
The long term goal of our collaborative effort is to bring precision medicine to the practice of veterinary oncology, using the wealth of genomic data gathered in human cancers as a roadmap....
Viruses and virally transmitted diseases have been impacting human health and well-being for hundreds of years. Some of our greatest scientific challenges and medical triumphs have involved...
Controlled Environment Agriculture (CEA) is predicted to reduce environmental impacts and build resilient, local agricultural systems. In addition to high-value food crops, CEA is used to cu...
G-protein coupled receptors (GPCRs) represent the single largest class of druggable targets in the human genome. Of the 390 or so druggable and non-olfactory human GPCRs there exist many whic...
Tuberculosis (TB) is the No.1 cause of death due to a single infectious agent in the world today. According to the global report from World Health Organization, one third of world population...
In our previous preclinical studies, when neural stem progenitor cells (NS/PCs)-derived from hiPSCs were transplanted into mouse or non-human primate spinal cord injury (SCI) models, long-ter...
Many of the most debilitating and life-threatening diseases are associated with the central nervous system. Some, such as neurodegenerative diseases, predominately afflict our aging populati...
The first small molecule inhibitor of the molecular chaperone Heat Shock Protein 90 (HSP90) was identified more than 20 years ago. Upon determination of the drug binding site and clarificatio...
Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
A recent clinical trial of the AR inhibitor enzalutamide in patients with TNBC included an exploratory endpoint using RNA sequencing to identify a genomic signature of patients likely to resp...
The nature of work in the clinical core lab has changed over the years from beakers of liquids, specimens and compounds on countertops to sophisticated equipment with prepackaged reagents and...
GeoMx Digital Spatial Profiling Technology! The GeoMx Digital Spatial Profiler (DSP) is a novel platform developed by NanoString. This leading digital technology offers multiplexed measureme...