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The idea of schizophrenia typically conjures up images of people who hear voices, see visions and have delusional beliefs. However, clinicians have long recognized cognitive dysfunction as on...
The emergence and spread of antimicrobial-resistant (AMR) bacteria and resistance mechanisms pose a serious challenge to laboratories in both hospital clinical microbiology and public health...
We are at a time where traditionally risk-adverse health care systems and their IT architecture are confronted with the deluge of data at a massive scale and tremendous variability. In many H...
The isolation of broadly-neutralizing antibodies from HIV-1 infected individuals raises the hope that a vaccine may elicit a similar immune response. These antibodies target the only viral pr...
T cells are the adaptive immune system’s first responders to any virus, circulating in the blood to detect and quickly multiply to attack the virus, and also support the development of...
Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...
The University of Louisville Infectious Diseases Laboratory (IDL) is a high-complexity, CLIA-certified laboratory in Louisville, KY. The IDL adopted the Luminex ARIES® platform in 2016 f...
Since the first introduction of the 3R concept in 1959 by Russell and Burch, there has been an increasing interest in finding alternatives to animal testing for ethical and economic reasons....
Biologics derived from mammalian sources are expected to undergo two orthogonal virus removal processes. One common processing step is a batch low-pH hold to inactivate enveloped viruses. At...
Biomarkers are critical tools for all stages of cancer research, from drug development through clinical applications. Cancer is fundamentally a disease of unregulated cell growth and circumv...
As next generation sequencing has lowered the price of DNA sequencing orders of magnitude below what it cost to create the first consensus human genome, the sheer diversity of human sequence...
Learning Objectives: 1. To understand the role of the US federal government in testing and other disease containment strategies 2. To understand how US federalism led to a diversity of respo...
Prokaryotes have long been at war with bacteriophage. The evolutionary pressure of this struggle has led both sides to develop sophisticated defenses. Notably, CRISPR-Cas systems evolved to l...
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high-frequency stim...
This presentation “SARS-CoV-2 Related Workflow and Solutions: Detection and Genotyping” will focus on strategies for the testing and detection of SARS-CoV-2, including multiplexe...
The IHME COVID-19 Projection Model has been two years in the making, and this talk will share details on how it works and what it says about our current point in the COVID pandemic as well a...
Clinical microbiology has experienced an unprecedented wave of innovation due to the introduction of advanced testing such as PCR, MALDI-TOF, and PNA-FISH. The wave of new technologies...
This presentation will focus on strategies for the design and validation of robust assays for the detection of SARS-CoV-2, including nucleic acid extraction, multiplexed qPCR assays, and int...
In the last decades, the upstream processing in biopharma industry has been revolutionized regarding the production of bioactive materials such as monoclonal antibodies, proteins and biother...
It is estimated that by the end of this year more than 1 million people worldwide will have had their genome sequenced. Genomic sequencing is increasingly being integrated into clinical care,...
DATE: February 9, 2017TIME: 9:00am PT, 12:00pm ETThe last few years have led to great progress in Chile in terms of laboratory animal care and use. There are new legal mandates to prote...
DATE: February 8, 2017TIME: 9:00am PT, Noon ETTraining programs for animal care and use personnel are integral to both animal welfare and quality research outcomes. There are a variety...
Therapeutic development for human diseases continues to face obstacles, particularly in translating targets or compounds identified by in vitro screening campaigns to valid targets or efficac...
The human inner ear contains ~75,000 sensory hair cells that detect sound or movement via mechanosensitive hair bundles and transmit signals to the brain via specialized sensory neurons. Inne...
High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance. Millipor...