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Big data has been with us for a long time, and tools to explore it continue to improve. Where are these data resources, how are we using them, and what are we finding as we explore them...
SELEX is a process that selects DNA or RNA from a random library of sequences based on their affinity for a target molecule. These high affinity ligands, called apta...
DATE: June 1, 2016
TIME: 10am Pacific time, 1pm Eastern time
On June 1st, join us for a webinar that’s designed to help you navigate your career in the right direction. We&rsq...
DATE: May 31, 2016
TIME: 7am Pacific time, 10am Easter time, 4pm Central European Summer time
Pipetting is an every-day task in a cell culture lab. We pipette so often that we...
A quick look at the most recent new drug filings reveals how much interest there is in biologically derived molecules as therapeutic agents. The majority of the filings are for New Biological...
Generating NGS data you can trust is highly reliant on the quality of the library sample that’s sequenced. NGS sample prep has become more streamlined, but it’s still a labo...
DATE: May 17, 2016
TIME: 7am Pacific time, 10am Eastern time, 4pm Swedish time
Data generation is becoming easier and easier and many organizations have matured in their data storage and ...
Millions of individuals have been sequenced or genotyped and linked with medical records, providing an exciting opportunity for therapeutic target discovery. My lab has been using a resilienc...
In order to realize the benefits of personalized cancer therapy, increasing demands are placed upon clinical laboratories to provide timely, comprehensive, clinically actionable, and analytic...
Network models are an invaluable tool for integrating multiple data types and for modeling interactions between biological elements. One common question that arises, however, is what to do wi...
The biological state of the cell is characterized by a complex network of interacting genes, gene products, proteins, microRNAs, as well as other molecules. Microarrays and next generation se...
DNA methylation is an essential mechanism of epigenetic gene regulation with broad relevance in development and disease. Its localization on genomic DNA and general stability make this epigen...
As millions of people all over the world get their genome sequenced, physicians and researchers as well as the individuals themselves will want to ask questions of these data. To ask question...
Circulating tumor cells (CTCs) is an emerging source used molecular cancer diagnostics. Through expression profiling of CTCs, it allows a deeper understanding about which metabolic pathways e...
Wolframin is a major protein of the endoplasmic reticulum, it is expressed in most tissues and clinical data demonstrate its significant connection to diabetes mellitus. L...
Technological advances allow for the large scale sequencing of the whole human genome. Most studies have generated population-based information on human diversity using low to intermediate co...
It is estimated that by the end of this year more than 1 million people worldwide will have had their genome sequenced. Genomic sequencing is increasingly being integrated into clinical care,...
The clinical utility of high-dimensional molecular profiling has been provisionally established in several domains of medicine. Today, interrogation of scores of genes and even whole ex...
The rapid implementation of next generation sequencing is changing how genetics and genomics are applied in a clinical setting. However, the quickly evolving technology can be challenging to...
Human breast tumors have been shown to exhibit extensive inter- and intra-tumor heterogeneity. While recent advances in genomic technologies have allowed us to deconvolute this heterogeneity,...
Technological advances have made genomic sequencing more affordable, efficient, and available. Questions related to the implementation and effects of large-scale sequencing in healthcare have...
Emerging technologies facilitate basic science research, but their value in regulatory applications requires rigorous assessment and consensus within the research community. Next-generation s...
DNASTAR offers an integrated suite of software for accurate assembly and analysis of sequence data from all major next-generation sequencing platforms supporting key workflows including de no...
We are at a time where traditionally risk-adverse health care systems and their IT architecture are confronted with the deluge of data at a massive scale and tremendous variability. In many H...
New approaches to generate high-quality representations of human genomes and transcriptomes are now becoming available. In contrast to short-read “Whole-Genome” re-sequencing meth...
Imaging-based techniques have traditionally been restricted to the diagnosis and staging of cancer. But technological advances are moving imaging modalities into the heart of patient care. Im...
In this time of incredible promise for genomic medicine, the Genomes2People (G2P) Research Program in Translational Genomics and Health Outcomes, directed by Robert C. Green, MD, MPH, is crea...