A scientific literature review published in the journal Molecules focused on the interactions of various cannabinoids, terpenes, and flavonoids in the cannabis plant. The review highlighted an emerging body of research that points to the potential health benefits of cannabis compound interactions. The review analyzed research studies that examined distinct ratios of cannabinoids, terpenes, and flavonoids in specific cannabis strains or products.
The review highlighted findings from different studies that examined the mechanisms involved in the entourage effect. The entourage effect is caused by the synergy of tetrahydrocannabinol (THC) and cannabidiol (CBD) and, along with many other cannabinoids, terpenes, and flavonoids, modulate mental and physical effects.
Cannabinoids and terpenes interact with the endocannabinoid system and can promote anti-pain, anti-inflammatory, and neuroprotective effects. Studies have indicated terpenes have pharmacological properties that can interact with neurotransmitter receptors, enzymes, and cell membranes and potentially enhance or modulate effects.
The review states, “The concept of the entourage effect suggests that the combined action of cannabinoids and terpenes may result in a synergistic or additive therapeutic effect greater than the sum of their individual effects.” Many studies have found these compound interactions can activate anti-inflammatory, antioxidant, and neuroprotective properties. Cannaflavins are specifically known for their anti-inflammatory benefits.
The review also emphasized that federal cannabis prohibition is a significant constraint on research on cannabis compounds and their potential therapeutic value. The researchers noted that “A comprehensive exploration of the synergies between cannabinoids, terpenes, and flavonoids, coupled with advancements in phytochemical research and the removal of regulatory barriers, holds the key to unlocking the full therapeutic potential of cannabis.” Future research studies should examine distinct ratios of cannabinoids, terpenes, and flavonoids in specific cannabis strains or products.
Sources: Marijuana Moment, Molecules
