Cannabinol (CBN) is a chemical found in cannabis that exhibits milder psychoactive properties than most cannabis chemicals, though research pertaining to its medical applications remains limited. Now, a team of researchers led by The Salk Institute for Biological Studies have published a study in Redox Biology that addresses the potential for CBN to serve as a method for neurological disorders, including traumatic brain injuries, Parkinson’s disease, and Alzheimer’s disease.
For the study, the researchers produced four CBN analogs that exhibited greater neuroprotective capabilities compared to the traditional CBN molecule and tested them on Drosophila fruit flies. In the end, the researchers discovered these CBN analogs possessed neuroprotective capabilities that surpassed traditional CBN molecules, including the treating of traumatic brain injuries. While not tested during this study, these CBN analogs could be used to also treat a myriad of neurological disorders, including Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease.
“Our findings help demonstrate the therapeutic potential of CBN, as well as the scientific opportunity we have to replicate and refine its drug-like properties,” said Dr. Pamela Maher, who is a research professor in the Cellular Neurobiology Laboratory at Salk and a co-author on the study. “Could we one day give this CBN analog to football players the day before a big game, or to car accident survivors as they arrive in the hospital? We’re excited to see how effective these compounds might be in protecting the brain from further damage.”
Going forward, the researchers aspire to expand the scope of this study by examining the CBN analogs’ influence on brain aging and cellular health, which they hope to accomplish through altering the CBN analog’s chemical designs.
How will CBN analogs help treat neurological disorders in the coming years and decades? Only time will tell, and this is why we science!
As always, keep doing science & keep looking up!
Sources: Redox Biology, EurekAlert!
