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    Translational Oncology

    Translational Oncology involves moving scientific discoveries made in a laboratory setting into clinical applications that enhance treatment efficacy and outcomes for cancer patients. Translational Oncology approaches include pre-clinical research, which can be done in an in vivo, in vitro, or ex vivo setting, before validating the laboratory findings with a clinical trial.

    Webinars

    • FEB 24, 2021 | 12:00 PM
      Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
      Deep Mechanistic profiling of immune oncology drug combinations...
      With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
      Speaker: Jason Frazier , Sarah Warren, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      Sponsored By: NanoString Technologies
      2
      FEB 24, 2021 | 7:30 AM
      Keynote Presentation: The biomarker to companion diagnostic continuum: a road map for the delivery of precision medicine
      Keynote Presentation: The biomarker to companion diagnostic continuum:...
      Specific biomarker assays are included in an increasing number of drug labels, with uses ranging from prediction of adverse events to providing insights on efficacy for patient populations....
      Speaker: Steven M. Anderson, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      2
      FEB 24, 2021 | 12:00 AM
      Multi-diagnostic approaches for patient selection in immuno-oncology
      Multi-diagnostic approaches for patient selection in immuno-oncology
      The development of different classes of immunotherapies that target cancer cells continues to be a rapidly growing area of research. The development of diagnostic tests which can predict pat...
      Speaker: Cindy Spittle
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      1
      FEB 03, 2021 | 8:00 AM
      An introduction to immuno-oncology at Miltenyi Biotec
      An introduction to immuno-oncology at Miltenyi Biotec
      Date: February 3, 2021 Time: 8:00am (PST), 11:00am (EST) This introduction webinar will provide you with an overview of the general immuno-oncology (IO) research field...
      Speaker: Dr. Marcello Stein
      Sponsored By: Miltenyi Biotec
      19 2
      JAN 12, 2021 | 8:00 AM
      Storage and Logistics of Vaccines at Ultra Low Temperatures
      Storage and Logistics of Vaccines at Ultra Low Temperatures
      DATE: January 12, 2021 TIME: 8:00 am PST, 11:00 am EST, 5:00pm CET Transferring a biologic candidate from the research and development phase to commercial production usually requires increas...
      Speaker: Dr. Alex Esmon
      Sponsored By: Thermo Fisher Scientific
      9
      DEC 07, 2020 | 9:00 AM
      Rapid hyper-plex staining and simultaneous imaging for immunophenotyping of tissue sections.
      Rapid hyper-plex staining and simultaneous imaging for immunophenotyping...
      Date: December 7, 2020 Time: 9:00am (PST), 12:00pm (EST) The simultaneous detection of biomarkers on tissue samples plays a fundamental role in the study of the tumor microenvironment. Multi...
      Speaker: Diego Dupouy, Ph.D.
      Sponsored By: Lunaphore
      7
      DEC 03, 2020 | 10:30 AM
      The Immunology of COVID-19: A dynamic immune signature for prognosis and spatial transcriptomics of lung tissue
      The Immunology of COVID-19: A dynamic immune signature for prognosis...
      The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 20...
      Speaker: Arutha Kulasinghe, PhD , Miguel Muñoz-Ruiz, PhD
      Presented at: Coronavirus Series
      Sponsored By: NanoString Technologies
      3
      DEC 02, 2020 | 8:00 AM
      Optimize your bioprocess - From shaker to bioreactor
      Optimize your bioprocess - From shaker to bioreactor
      DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
      Speaker: Ines Hartmann , David Solbach
      Sponsored By: Eppendorf
      11
      NOV 12, 2020 | 3:00 PM
      Translating insights into better outcomes: The new QIAseq Human Exome integrated solution
      Translating insights into better outcomes: The new QIAseq Human...
      What if your lab could perform exome sequencing with the same sensitivity and efficiency of targeted sequencing? The new integrated QIAseq Human Exome TR Insights solution from QIAGEN delive...
      Speaker: Brian Dugan, M.S. , Rupert Yip, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2020
      Sponsored By: QIAGEN
      1
      NOV 12, 2020 | 9:00 AM
      Back to Work, School, and Life: Utility of COVID-19 Testing to Help Communities Restore Normality
      Back to Work, School, and Life: Utility of COVID-19 Testing to...
      Testing volumes need to increase by orders of magnitude in order to restore communities back to normality. This workshop focuses on solutions that equip laboratories to participate in expand...
      Speaker: Dr. Jared R. Auclair , Frank Ong, MD, CPI, CCRP
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2020
      Sponsored By: Thermo Fisher Scientific
      5
      NOV 12, 2020 | 12:00 AM
      The Importance of Tissue Chemistry in Immunity-Oncology
      The Importance of Tissue Chemistry in Immunity-Oncology
      Cancer cells can acquire immune resistance resulting in a loss of immunosurveillance. Tumor cells can upregulate PDL-1 which binds to PD-1. This complex inhibits CD8 Tumor Infiltrating cells...
      Speaker: Thomas M. Grogan, MD
      Presented at: DISCOVERY Global User Symposium
      0
      OCT 22, 2020 | 1:35 PM
      Evaluation of the Oncomine Comprehensive Assay Plus for Profiling of Solid Tumours
      Evaluation of the Oncomine Comprehensive Assay Plus for Profiling...
      Precision oncology continues to evolve as additional clinically relevant biomarkers are identified. The challenges facing the clinical researchers include not only the ability to add additio...
      Speaker: Jane Bayani, PhD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      0
      OCT 22, 2020 | 1:35 PM
      Evaluation of the Oncomine Comprehensive Assay Plus for Profiling of Solid Tumours
      Evaluation of the Oncomine Comprehensive Assay Plus for Profiling...
      Precision oncology continues to evolve as additional clinically relevant biomarkers are identified. The challenges facing both diagnostic laboratories and clinicians include not only the abi...
      Speaker: Jane Bayani, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      OCT 22, 2020 | 12:25 PM
      Clinical impact of Next-Generation Sequencing (NGS) Testing: A hematopathologist's perspective
      Clinical impact of Next-Generation Sequencing (NGS) Testing: A...
      Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
      Speaker: Megan S. Lim, MD, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      2
      OCT 22, 2020 | 12:25 PM
      Clinical impact of Next-Generation Sequencing (NGS) Testing: A hematopathologist's perspective
      Clinical impact of Next-Generation Sequencing (NGS) Testing: A...
      Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
      Speaker: Megan S. Lim, MD, PhD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      0
      OCT 22, 2020 | 6:35 AM
      Next Generation rEvolution in Myeloid Neoplasms clinical research
      Next Generation rEvolution in Myeloid Neoplasms clinical research
      Myeloid neoplasms are a group of heterogeneus disorders originating from the neoplastic transformation of a pluripotent hematopoietic progenitor cell. Following the acquisition of somatic mu...
      Speaker: Giada Rotunno, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      OCT 22, 2020 | 6:35 AM
      Next Generation rEvolution in Myeloid Neoplasms clinical research
      Next Generation rEvolution in Myeloid Neoplasms clinical research
      Myeloid neoplasms are a group of heterogeneus disorders originating from the neoplastic transformation of a pluripotent hematopoietic progenitor cell. Following the acquisition of somatic mu...
      Speaker: Giada Rotunno, PhD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      0
      OCT 22, 2020 | 6:05 AM
      NGS for precision oncology in solid tumors: from research to clinical practice
      NGS for precision oncology in solid tumors: from research to clinical...
      Precision oncology is revolutionizing the diagnostic and therapeutic approach to cancer. In fact, the availability of tumor-specific and tumor-agnostic biomarkers and matched therapies is ra...
      Speaker: Nicola Normanno, MD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      OCT 22, 2020 | 6:05 AM
      NGS for precision oncology in solid tumors: from research to clinical practice
      NGS for precision oncology in solid tumors: from research to clinical...
      Precision oncology is revolutionizing the diagnostic and therapeutic approach to cancer. In fact, the availability of tumor-specific and tumor-agnostic biomarkers and matched therapies is ra...
      Speaker: Nicola Normanno, MD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      0
      OCT 21, 2020 | 9:05 PM
      Incorporating NGS in an Asian non-small cell lung cancer (NSCLC) population - a cost-effectiveness analysis
      Incorporating NGS in an Asian non-small cell lung cancer (NSCLC)...
      There is an expanding list of therapeutically relevant biomarkers for non-small cell lung cancer (NSCLC), and molecular profiling at diagnosis is paramount. Tissue attrition in scaling tradi...
      Speaker: Aaron Tan, PhD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      0
      OCT 21, 2020 | 9:05 PM
      Incorporating NGS in an Asian non-small cell lung cancer (NSCLC) population - a cost-effectiveness analysis
      Incorporating NGS in an Asian non-small cell lung cancer (NSCLC)...
      There is an expanding list of therapeutically relevant biomarkers for non-small cell lung cancer (NSCLC), and molecular profiling at diagnosis is paramount. Tissue attrition in scaling tradi...
      Speaker: Aaron Tan, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      OCT 15, 2020 | 9:00 AM
      Evaluating the Kidney-Chip for Transporter-Mediated Drug-Drug Interactions Applications
      Evaluating the Kidney-Chip for Transporter-Mediated Drug-Drug...
      Date: October 15, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Renal transporters play an important role in potential clinical drug-drug interactions (DDIs) as highlighted in the FDA, EMA and PMDA...
      Speaker: Steven Anderson, PhD , Kyung-Jin Jang, PhD , Donald McKenzie, PhD
      Sponsored By: Emulate
      9
      OCT 13, 2020 | 2:30 PM
      Panel Discussion: Cancer Care in different regions and what are the current standard of care in Lung cancer
      Panel Discussion: Cancer Care in different regions and what are...
      ...
      Speaker: Arjun Khanna , David Chi Leung Lam, MD, PhD , Chein-Feng Li, MD , Darren Wan Teck Lim
      Presented at: 10 Million Reasons to Defeat Cancer - 2020 Abbott World Summit
      1
      OCT 08, 2020 | 10:00 AM
      The importance of liquid biopsy MSI for studying tumors and immunotherapy applications
      The importance of liquid biopsy MSI for studying tumors and immunotherapy...
      DATE: October 8, 2020 TIME: 1:00pm PDT Microsatellite instability (MSI) has evolved as a marker of potential hereditary cancer risk and is now a tissue agnostic immune biomarker with a broad...
      Speaker: Paul Walker, MD, FACP
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      9
    FEB 24, 2021 | 12:00 PM
    Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
    Deep Mechanistic profiling of immune oncology drug combinations...
    With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
    Speaker: Jason Frazier , Sarah Warren, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    Sponsored By: NanoString Technologies
    2
    FEB 24, 2021 | 7:30 AM
    Keynote Presentation: The biomarker to companion diagnostic continuum: a road map for the delivery of precision medicine
    Keynote Presentation: The biomarker to companion diagnostic continuum:...
    Specific biomarker assays are included in an increasing number of drug labels, with uses ranging from prediction of adverse events to providing insights on efficacy for patient populations....
    Speaker: Steven M. Anderson, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    2
    FEB 24, 2021 | 12:00 AM
    Multi-diagnostic approaches for patient selection in immuno-oncology
    Multi-diagnostic approaches for patient selection in immuno-oncology
    The development of different classes of immunotherapies that target cancer cells continues to be a rapidly growing area of research. The development of diagnostic tests which can predict pat...
    Speaker: Cindy Spittle
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    1
    FEB 03, 2021 | 8:00 AM
    An introduction to immuno-oncology at Miltenyi Biotec
    An introduction to immuno-oncology at Miltenyi Biotec
    Date: February 3, 2021 Time: 8:00am (PST), 11:00am (EST) This introduction webinar will provide you with an overview of the general immuno-oncology (IO) research field...
    Speaker: Dr. Marcello Stein
    Sponsored By: Miltenyi Biotec
    19 2
    JAN 12, 2021 | 8:00 AM
    Storage and Logistics of Vaccines at Ultra Low Temperatures
    Storage and Logistics of Vaccines at Ultra Low Temperatures
    DATE: January 12, 2021 TIME: 8:00 am PST, 11:00 am EST, 5:00pm CET Transferring a biologic candidate from the research and development phase to commercial production usually requires increas...
    Speaker: Dr. Alex Esmon
    Sponsored By: Thermo Fisher Scientific
    9
     
     
  • DEC 07, 2020 | 9:00 AM
    Rapid hyper-plex staining and simultaneous imaging for immunophenotyping of tissue sections.
    Rapid hyper-plex staining and simultaneous imaging for immunophenotyping...
    Date: December 7, 2020 Time: 9:00am (PST), 12:00pm (EST) The simultaneous detection of biomarkers on tissue samples plays a fundamental role in the study of the tumor microenvironment. Multi...
    Speaker: Diego Dupouy, Ph.D.
    Sponsored By: Lunaphore
    7
    DEC 03, 2020 | 10:30 AM
    The Immunology of COVID-19: A dynamic immune signature for prognosis and spatial transcriptomics of lung tissue
    The Immunology of COVID-19: A dynamic immune signature for prognosis...
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 20...
    Speaker: Arutha Kulasinghe, PhD , Miguel Muñoz-Ruiz, PhD
    Presented at: Coronavirus Series
    Sponsored By: NanoString Technologies
    3
    DEC 02, 2020 | 8:00 AM
    Optimize your bioprocess - From shaker to bioreactor
    Optimize your bioprocess - From shaker to bioreactor
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    Speaker: Ines Hartmann , David Solbach
    Sponsored By: Eppendorf
    11
    NOV 12, 2020 | 3:00 PM
    Translating insights into better outcomes: The new QIAseq Human Exome integrated solution
    Translating insights into better outcomes: The new QIAseq Human...
    What if your lab could perform exome sequencing with the same sensitivity and efficiency of targeted sequencing? The new integrated QIAseq Human Exome TR Insights solution from QIAGEN delive...
    Speaker: Brian Dugan, M.S. , Rupert Yip, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2020
    Sponsored By: QIAGEN
    1
    NOV 12, 2020 | 9:00 AM
    Back to Work, School, and Life: Utility of COVID-19 Testing to Help Communities Restore Normality
    Back to Work, School, and Life: Utility of COVID-19 Testing to...
    Testing volumes need to increase by orders of magnitude in order to restore communities back to normality. This workshop focuses on solutions that equip laboratories to participate in expand...
    Speaker: Dr. Jared R. Auclair , Frank Ong, MD, CPI, CCRP
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2020
    Sponsored By: Thermo Fisher Scientific
    5
     
     
  • NOV 12, 2020 | 12:00 AM
    The Importance of Tissue Chemistry in Immunity-Oncology
    The Importance of Tissue Chemistry in Immunity-Oncology
    Cancer cells can acquire immune resistance resulting in a loss of immunosurveillance. Tumor cells can upregulate PDL-1 which binds to PD-1. This complex inhibits CD8 Tumor Infiltrating cells...
    Speaker: Thomas M. Grogan, MD
    Presented at: DISCOVERY Global User Symposium
    0
    OCT 22, 2020 | 1:35 PM
    Evaluation of the Oncomine Comprehensive Assay Plus for Profiling of Solid Tumours
    Evaluation of the Oncomine Comprehensive Assay Plus for Profiling...
    Precision oncology continues to evolve as additional clinically relevant biomarkers are identified. The challenges facing the clinical researchers include not only the ability to add additio...
    Speaker: Jane Bayani, PhD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    0
    OCT 22, 2020 | 1:35 PM
    Evaluation of the Oncomine Comprehensive Assay Plus for Profiling of Solid Tumours
    Evaluation of the Oncomine Comprehensive Assay Plus for Profiling...
    Precision oncology continues to evolve as additional clinically relevant biomarkers are identified. The challenges facing both diagnostic laboratories and clinicians include not only the abi...
    Speaker: Jane Bayani, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    OCT 22, 2020 | 12:25 PM
    Clinical impact of Next-Generation Sequencing (NGS) Testing: A hematopathologist's perspective
    Clinical impact of Next-Generation Sequencing (NGS) Testing: A...
    Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
    Speaker: Megan S. Lim, MD, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    2
    OCT 22, 2020 | 12:25 PM
    Clinical impact of Next-Generation Sequencing (NGS) Testing: A hematopathologist's perspective
    Clinical impact of Next-Generation Sequencing (NGS) Testing: A...
    Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leuke...
    Speaker: Megan S. Lim, MD, PhD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    0
     
     
  • OCT 22, 2020 | 6:35 AM
    Next Generation rEvolution in Myeloid Neoplasms clinical research
    Next Generation rEvolution in Myeloid Neoplasms clinical research
    Myeloid neoplasms are a group of heterogeneus disorders originating from the neoplastic transformation of a pluripotent hematopoietic progenitor cell. Following the acquisition of somatic mu...
    Speaker: Giada Rotunno, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    OCT 22, 2020 | 6:35 AM
    Next Generation rEvolution in Myeloid Neoplasms clinical research
    Next Generation rEvolution in Myeloid Neoplasms clinical research
    Myeloid neoplasms are a group of heterogeneus disorders originating from the neoplastic transformation of a pluripotent hematopoietic progenitor cell. Following the acquisition of somatic mu...
    Speaker: Giada Rotunno, PhD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    0
    OCT 22, 2020 | 6:05 AM
    NGS for precision oncology in solid tumors: from research to clinical practice
    NGS for precision oncology in solid tumors: from research to clinical...
    Precision oncology is revolutionizing the diagnostic and therapeutic approach to cancer. In fact, the availability of tumor-specific and tumor-agnostic biomarkers and matched therapies is ra...
    Speaker: Nicola Normanno, MD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    OCT 22, 2020 | 6:05 AM
    NGS for precision oncology in solid tumors: from research to clinical practice
    NGS for precision oncology in solid tumors: from research to clinical...
    Precision oncology is revolutionizing the diagnostic and therapeutic approach to cancer. In fact, the availability of tumor-specific and tumor-agnostic biomarkers and matched therapies is ra...
    Speaker: Nicola Normanno, MD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    0
    OCT 21, 2020 | 9:05 PM
    Incorporating NGS in an Asian non-small cell lung cancer (NSCLC) population - a cost-effectiveness analysis
    Incorporating NGS in an Asian non-small cell lung cancer (NSCLC)...
    There is an expanding list of therapeutically relevant biomarkers for non-small cell lung cancer (NSCLC), and molecular profiling at diagnosis is paramount. Tissue attrition in scaling tradi...
    Speaker: Aaron Tan, PhD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    0
     
     
  • OCT 21, 2020 | 9:05 PM
    Incorporating NGS in an Asian non-small cell lung cancer (NSCLC) population - a cost-effectiveness analysis
    Incorporating NGS in an Asian non-small cell lung cancer (NSCLC)...
    There is an expanding list of therapeutically relevant biomarkers for non-small cell lung cancer (NSCLC), and molecular profiling at diagnosis is paramount. Tissue attrition in scaling tradi...
    Speaker: Aaron Tan, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    OCT 15, 2020 | 9:00 AM
    Evaluating the Kidney-Chip for Transporter-Mediated Drug-Drug Interactions Applications
    Evaluating the Kidney-Chip for Transporter-Mediated Drug-Drug...
    Date: October 15, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Renal transporters play an important role in potential clinical drug-drug interactions (DDIs) as highlighted in the FDA, EMA and PMDA...
    Speaker: Steven Anderson, PhD , Kyung-Jin Jang, PhD , Donald McKenzie, PhD
    Sponsored By: Emulate
    9
    OCT 13, 2020 | 2:30 PM
    Panel Discussion: Cancer Care in different regions and what are the current standard of care in Lung cancer
    Panel Discussion: Cancer Care in different regions and what are...
    ...
    Speaker: Arjun Khanna , David Chi Leung Lam, MD, PhD , Chein-Feng Li, MD , Darren Wan Teck Lim
    Presented at: 10 Million Reasons to Defeat Cancer - 2020 Abbott World Summit
    1
    OCT 08, 2020 | 10:00 AM
    The importance of liquid biopsy MSI for studying tumors and immunotherapy applications
    The importance of liquid biopsy MSI for studying tumors and immunotherapy...
    DATE: October 8, 2020 TIME: 1:00pm PDT Microsatellite instability (MSI) has evolved as a marker of potential hereditary cancer risk and is now a tissue agnostic immune biomarker with a broad...
    Speaker: Paul Walker, MD, FACP
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    9
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