Evaluating the Kidney-Chip for Transporter-Mediated Drug-Drug Interactions Applications

Renal transporters play an important role in potential clinical drug-drug interactions (DDIs) as highlighted in the FDA, EMA and PMDA regulatory guidance documents. Conventionally available experimental models yield data on limited numbers of transporters in a given system. This is generally not predictive of clinical outcomes due to in vitro-in vivo discrepancies because of the interplay of multiple transporters in the proximal tubule. Since DDIs are important to clinical outcomes, with the ever increasing amount of polypharmacy there is an unmet need for a human-relevant model to study renal drug transport.

 

Covance and Emulate are collaborating to evaluate the Proximal Tubule Kidney-Chip to study transporter-mediated DDIs to fill the gap between current in vitro options and clinical trials.

 

In this webinar, scientists from Emulate and Covance will showcase promising new data on characterization of the Kidney-Chip as a model to study and predict potential drug-drug interactions. There will be three webinar speakers: