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PTEN
PTEN is a human gene coding for an enzyme called phosphatase and tensin homolog (PTEN). PTEN in a tumor suppressor gene which prevents mutations from occurring in genetic code. Therefore, mutations in PTEN are prevalent in many malignancies including brain, breast, lung, and prostate cancers.
MAY 19, 2020 | 12:45 PM
Background: Pathologists have long recognized that the interaction between immune and tumour cells is critical in the development and progression of breast cancer. Studies have demonstrated...
APR 10, 2019 | 12:00 PM
Determining which patients would derive clinical benefit from immunotherapy is a compelling clinical question. Biomarkers have been shown to predict therapy outcome in various types of cancer...
OCT 11, 2018 | 9:00 AM
The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
MAR 15, 2018 | 9:00 AM
The inability of neurons to regenerate damaged axons within the CNS has dire consequences for victims of traumatic or ischemic brain injury and multiple neurodegenerative diseases. Like other...
OCT 12, 2017 | 10:30 AM
Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of only 9%. Acquired drug resistance is a major factor that limits the effectiveness of chemotherapy. Exosomes, secreted...
JAN 26, 2016 | 8:00 AM
DATE: January 26th, 2016
TIME: 8am pacific, 11am eastern
PTEN gene loss occurs frequently in castration-resistant prostate cancer (CRPC) and may drive progression through activation of th...
MAY 14, 2015 | 1:30 PM
Germline cancer genetics became a reality with the cloning of the tumor suppressor gene RB1 for hereditary retinoblastoma in 1986 by Friend and Weinberg. The existence of cancer susceptibili...
SEP 16, 2014 | 9:30 AM
Late-stage drug attrition rates in oncology remain higher than in other therapeutic areas. To reduce attrition, it is critical to identify appropriate drug targets and pre-clinical models. Th...
FEB 05, 2014 | 2:00 PM
C.E. CREDITS
It is increasingly recognized that the genetic background (i.e., all genomic sequences other than the gene(s) of interest) can have profound influences on the phenotype of an animal model. I...