Motor control: systematic regulation of movement in organisms that have a nervous system. Also includes movement functions which can be attributed to reflexes.
In this talk, I will discuss the development of interpretable machine learning models to test scientific hypotheses, with a specific focus on spinal motor control. Voluntary movement require...
One role of theory is in guiding future experiments: What should we aim to measure? Which experimental results should we be surprised about? I will argue here that simple random networks mod...
More than 50,700 Americans died of opioid overdose in 2019, and more than 1.6 million Americans live with addiction to opioids. Moreover, more than 50 million Americans suffer from chronic p...
Similar to the “histone code” hypothesis in which epigenetic marks on histone tails expand the information potential of the genetic code, different tubulin isoforms, combined wit...
Learning is often an emotional process. Emotional stimuli with different valences, such as threat and reward, can transform an otherwise neutral sensory input into one that can trigger disti...
Approximately 300,000 people in the United States have a spinal cord injury with many of these individuals experiencing permanent motor and sensory deficits. For individuals with cervical sp...
Brain machine interfaces (BMIs) aim to help patients with paralysis to use their recorded brain activity to control assistive devices. BMI research requires the collaboration of neuroscienti...
Mechanistic understanding of neural systems is daunting to achieve in large part due to the heterogeneity of the neuronal elements in both form and function and the complexity of the circuit...
The neural basis of simple rhythmic and reflexive behaviors such as swimming and gill withdrawal have been successfully studied in nudibranchs and other gastropod molluscs because the brains...
The locomotion of humans and other animals requires a seamless flow of information from sensory modalities all the way to the motor periphery. As such, locomotion is an excellent system for...
Normal behavior in any moving animal, including humans, relies on communication between motor systems that control movements, and the sensory systems we use to guide these actions. A critica...
Brain machine interfaces or neural prosthetics have the potential to restore movement to people with paralysis or amputation, bridging gaps in the nervous system with an artificial device. M...
Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
Deep brain stimulation (DBS) is an established therapy for cardinal motor signs and medication-related complications in Parkinson’s disease (PD). Current DBS therapy is limited to &ldqu...
Humans interact with their environment in countless ways and can switch seamlessly between activities. Even for seemingly simple tasks, a variety of sensory inputs and contextual cues are int...
Drug overdose surpassed motor vehicle accidents as the leading cause of accidental death 2006 and has remained the leading cause of accidental death at the state and national level. Mos...
The study of rare, neurological disorder and the development of effect treatments can pose many unique challenges. A paucity of scientists working on these disorders often limits forward prog...
The cerebellum is incorporated into the distributed neural circuits subserving motor control, cognitive processing and the modulation of emotion. This lecture provides an overview of anatomic...
The enteric nervous system (ENS) plays an essential role in gut motility. Diseases of the ENS result in bowel motility disorders that are some of the most challenging clinical conditions to m...
Disease-specific human pluripotent stem cells (hPSCs) represent a new chance to unravel cellular and molecular mechanisms of neurological diseases. Along this line, we were among the first to...
A fundamental challenge in developing brain machine interfaces (BMIs) is building a decoder between patterns of brain activity and movement in patients with spinal cord injury, ALS, and amput...
In this talk, I will discuss the development of interpretable machine learning models to test scientific hypotheses, with a specific focus on spinal motor control. Voluntary movement require...
One role of theory is in guiding future experiments: What should we aim to measure? Which experimental results should we be surprised about? I will argue here that simple random networks mod...
More than 50,700 Americans died of opioid overdose in 2019, and more than 1.6 million Americans live with addiction to opioids. Moreover, more than 50 million Americans suffer from chronic p...
Similar to the “histone code” hypothesis in which epigenetic marks on histone tails expand the information potential of the genetic code, different tubulin isoforms, combined wit...
Learning is often an emotional process. Emotional stimuli with different valences, such as threat and reward, can transform an otherwise neutral sensory input into one that can trigger disti...
Approximately 300,000 people in the United States have a spinal cord injury with many of these individuals experiencing permanent motor and sensory deficits. For individuals with cervical sp...
Brain machine interfaces (BMIs) aim to help patients with paralysis to use their recorded brain activity to control assistive devices. BMI research requires the collaboration of neuroscienti...
Mechanistic understanding of neural systems is daunting to achieve in large part due to the heterogeneity of the neuronal elements in both form and function and the complexity of the circuit...
The neural basis of simple rhythmic and reflexive behaviors such as swimming and gill withdrawal have been successfully studied in nudibranchs and other gastropod molluscs because the brains...
The locomotion of humans and other animals requires a seamless flow of information from sensory modalities all the way to the motor periphery. As such, locomotion is an excellent system for...
Normal behavior in any moving animal, including humans, relies on communication between motor systems that control movements, and the sensory systems we use to guide these actions. A critica...
Brain machine interfaces or neural prosthetics have the potential to restore movement to people with paralysis or amputation, bridging gaps in the nervous system with an artificial device. M...
Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
Deep brain stimulation (DBS) is an established therapy for cardinal motor signs and medication-related complications in Parkinson’s disease (PD). Current DBS therapy is limited to &ldqu...
Humans interact with their environment in countless ways and can switch seamlessly between activities. Even for seemingly simple tasks, a variety of sensory inputs and contextual cues are int...
Drug overdose surpassed motor vehicle accidents as the leading cause of accidental death 2006 and has remained the leading cause of accidental death at the state and national level. Mos...
The study of rare, neurological disorder and the development of effect treatments can pose many unique challenges. A paucity of scientists working on these disorders often limits forward prog...
The cerebellum is incorporated into the distributed neural circuits subserving motor control, cognitive processing and the modulation of emotion. This lecture provides an overview of anatomic...
The enteric nervous system (ENS) plays an essential role in gut motility. Diseases of the ENS result in bowel motility disorders that are some of the most challenging clinical conditions to m...
Disease-specific human pluripotent stem cells (hPSCs) represent a new chance to unravel cellular and molecular mechanisms of neurological diseases. Along this line, we were among the first to...
A fundamental challenge in developing brain machine interfaces (BMIs) is building a decoder between patterns of brain activity and movement in patients with spinal cord injury, ALS, and amput...
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