Microglia: glial cells, derived from the germ layer, mesoderm, that function as scavengers (macrophages) in the central nervous system. This, in turn, forms part of the reticuloendothelial system.
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C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and result in both loss of C9orf72 protein expression and production of potentially...
MAR 08, 2023 | 6:00 AM
C.E. CREDITS
Mild traumatic brain injuries (mTBIs) are a prevalent health issue in North America. There is increasing pressure to utilize ecologically valid models of closed-head mTBI in the preclinical...
FEB 23, 2023 | 8:00 AM
C.E. CREDITS
Date: February 23, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) The RNAscope in situ hybridization (ISH) technology is a powerful method for detecting gene expression with spatial an...
Neurological manifestations, including headache, altered mental status, and stroke, are a major complication of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and cor...
In this preliminary experiment, we used spatial transcriptomics to assess the gene expression profiles of microglia or astrocytes in relation to their distance from plaques. We compared 18-m...
Date: June 10, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Microglia, the primary brain macrophages, regulate a plethora of processes that impact the organization of neural circuits, including sy...
Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
Brain malignancies can either originate from within the CNS (gliomas) or invade from other locations in the body (metastases). A highly immunosuppressive tumor microenvironment (TME) influen...
The accumulation of neurotoxic amyloid beta peptides and/or neurofibrillary tangle formation are key pathological hallmarks of neurodegenerative diseases including but not limited to Alzheim...