Mechanotransduction is a process by which cells actively sense, integrate, and convert stimuli into biochemical signals that lead to intracellular changes. Mechanotransduction facilitates processes like changing ion concentrations, activating signaling pathways, and regulating transcription. Systems biology involves mathematic analysis to model biological systems. Mechanotransduction systems biology combines these fields of science resulting in a focus on a computational approach to stimuli-driven cellular changes.