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Liver diseases
Liver diseases are characterized by their damaging impacts on hepatic tissue. Many liver diseases are caused by viruses, such as hepatitis A, B, and C. Other liver diseases, including cirrhosis, can also be driven by drug or alcohol abuse, and exposure to toxins or poisons. Additionally, some liver diseases, such as Wilson disease, are genetically passed through generations.
JAN 01, 2020 | 6:00 AM
The liver plays a critical role in the metabolism and clearance of more than 70% of marketed drugs. Furthermore, toxicity to the liver is a major reason for preclinical and clinical drug fai...
JAN 01, 2020 | 6:00 AM
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in developed countries, and it affects over 25% of the population worldwide. Within the next five y...
JAN 01, 2020 | 6:00 AM
The OrganoPlate is a microtiterplate based Organ-on-a-Chip platform for high throughput drug safety and efficacy screening. It contains up to 96 cell culture chambers that allow co-culture o...
JAN 01, 2020 | 6:00 AM
The aim of the lecture is to give an insight into the use of 3D liver micro tissues (3D liMTs) in drug discovery and translational safety. In translational toxicology, 3D LiMTs have a high i...
JAN 01, 2020 | 6:00 AM
Microphysiological systems (MPS), also known as organ-on-chips, are small scale in vitro cell cultures which mimic facets of tissue or organ level function. MPS frequently utilise primary hu...
DEC 17, 2019 | 9:00 AM
DATE: December 17, 2019TIME: 9:00am PST, 12:00pm EST Purpose: Liver x receptors (LXRs) are hypothesized to serve as a link between lipid metabolism and inflammation by prom...
DEC 05, 2019 | 5:00 AM
DATE: December 5, 2019TIME: 5:00am PST, 8:00am EST The diagnosis of an active infection by the hepatitis B virus (HBV) relies on testing for the HBV surface antigen (HBsAg). Ov...
NOV 21, 2019 | 9:00 AM
DATE: November 21, 2019TIME: 9:00am PST, 12:00pm EST Multiple Myeloma is a disease of terminally differentiated plasma cells with the massive production of monoclonal immunoglobu...
NOV 19, 2019 | 10:00 AM
DATE: November 19, 2019TIME: 10:00am PSTMicroglial cells are the resident innate immune cells of the central nervous system (CNS) and are responsible for regulating inflammatory activati...
OCT 31, 2019 | 9:00 AM
DATE: October 31, 2019TIME: 9:00am PDT, 12:00pm EDT INTRODUCTION: A major limitation for the development of 3D engineered tissues is the absence of viable and perfusable...
OCT 29, 2019 | 7:00 AM
DATE: October 29, 2019TIME: 7:00am PDT3D cell culture systems have recently emerged as tools for reproducing the cellular environment and the organization of tissues/organs, where cel...
OCT 22, 2019 | 8:00 AM
Calprotectin is a member of the S100 family of calcium binding proteins, being a hetero dimmer of S100A8/9 and accounts for 60% of the protein in the cytoplasm of neutrophils. It is released...
SEP 09, 2019 | 8:00 AM
Standardization and harmonization have come a long way in the last 3 to 4 decades; however, standardization is imperfect. Laboratory professional need to recognize the limitations of some of...
AUG 27, 2019 | 8:00 AM
DATE: August 27, 2019TIME: 08:00 AM PDTOur laboratory is exploring hypotheses about how lipid metabolism contributes to racial disparities in Alzheimer’s disease using comprehen...
MAY 15, 2019 | 12:00 PM
DATE: May 15, 2019TIME: 9:00am PDTHepatitis B infections remain a significant global healthcare burden resulting in 887,000 deaths in 2015. Clinical laboratories can have a measurable i...
APR 17, 2019 | 9:00 AM
DATE: April 17, 2019TIME: 9:00am PDT...
FEB 27, 2019 | 1:30 PM
Isolated hepatocytes or their enzymes comprise the basis of most in vitro DMPK and toxicity assays used to predict human hepatic outcomes. Because hepato-specific functions are typically lost...
NOV 29, 2018 | 7:00 AM
DATE: November 29, 2018TIME: 15:00pm WET, 07:00am PST O vírus da Hepatite C (HCV) é uma infeção mundial, que...
NOV 15, 2018 | 6:00 AM
DATE: November 15,2018TIME: 06:00am PST, 09:00am EST, 3:00pm CET Hepatitis D virus (HDV) is a unique RNA virus that requires the hepatitis B surface antigen (HBsAg) to...
NOV 14, 2018 | 3:00 PM
Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...