Liposome is defined as the nanosized vesicular structure consisting of an aqueous core surrounded with phospholipid layers. Liposomes have been used to improve the therapeutic index of new or established drugs by modifying drug absorption, reducing metabolism, prolonging biological half-life or reducing toxicity. Liposomes can be prepared by disrupting biological membranes.
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Most FDA-approved therapeutic drugs target transmembrane proteins, yet the development of monoclonal antibodies for multi-transmembrane protein targets has been limited. Despite the abundanc...
Date: June 16, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Lipid-based nanoparticles (LNPs) are effective non-viral vectors for delivering messenger RNA products (mRNA), most notab...
The past few decades have seen a substantial increase in the research based on nanocarrier based combinative drug therapies in various diseases such as cancer, tuberculosis, Alzheimer’...
DATE: October 1, 2019TIME: 8:00am PTIn the webinar, Introduction to Characterization of Biomolecules Using Analytical Ultracentrifugation, we discussed the fundamentals of analytical...
DATE: June 18, 2019TIME: 08:00am PDTAnalytical Ultracentrifugation (AUC) is one of the most powerful biophysical tools used today for the characterization of biological samples ranging...
In-vitro epithelial barrier models that are more representative of in-vivo tissues are urgently needed. Here we present extracellular matrix-supported intestinal tubules in a perfused microfl...
In the last years a number of advanced nanotechnologies have been proposed developed for the administration of drugs (nanomedicines for drug delivery), in order to provide possibilities...
CRISPR-Cas9 systems provide a platform for high efficiency genome editing that are enabling innovative applications of mammalian cell engineering. The delivery of Cas9 plasmid DNA or mR...