In Vitro: refers to a medical test or experiment/procedure that is conducted in a laboratory within the confines of a test tube or laboratory dish. This is not to be confused with the term in vivo, which is a medical test or procedure that is performed on or in a living organism.
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CRISPR ribonucleoproteins (RNPs) can generate programmable gene edits, however imprecise editing and efficient delivery to human stem cells are key challenges. Here we describe novel biochemi...
The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...
DATE: November 13, 2018TIME: 9:00am PST, 12:00pm ESTExtracellular vesicles (EVs) are cell-secreted nanoparticles that play a pivotal role in intercellular communic...
The last decade has seen a significant shift in the way that mammalian cells are used in biomedical science. Researchers are increasingly turning from simple, reductionist recombinant cells t...
The success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on cancer cell and immune cell interaction, how cancer cells i...
Integrated protocols and live-cell analysis solutions for different 3D tumor modelsIn the search for greater clinical translation, cancer researchers are increasingly turning to more comp...
Deriving deeper biological insight & improving productivity in immune-cell biologyThe most common in vitro methods for immunologists to analyze cells of the immune system are flow cyt...
DATE: October 25, 2018TIME: 08:00am PDT, 11:00am EDT While the significance of the microbiome is unprecedented, a thorough study to dissect the role of individual popul...
Solid phase microextraction (SPME) is a versatile, non-exhaustive sample preparation tool that has been demonstrated to be well-suited for facile and effective analysis of a broad range of co...
DATE: October 23, 2018TIME: 9:00AM PDTIxodes scapularis is the principal vector of the Lyme disease spirochete, Borrelia burgdorferi. I. scapularis genome was the first and only...
DATE: October 23, 2018TIME: 7:00AM PDTHigh Throughput Screening for the European Lead Factory (ELF) has been performed at Pivot Park Screening Centre (PPSC). 72 HTS campaigns have...
Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between...
In prior work, we have pursued how tumor reactive monoclonal antibody (mAb), together with activators of innate immune cells, like NK cells, can augment antibody dependent cell-mediated cytot...
Pancreatic β cell replacement therapy is considered as a potential strategy to treat diabetes. To date, transplantation of pancreatic islets from cadavers is the most effective approach...
Lowe Syndrome (LS) is a devastating genetic disease characterized by abnormalities in the eyes, brain and kidneys that unfortunately leads to the premature death of affected children due to r...