Environment: The natural environment encompasses all living and non-living things occurring naturally, meaning in this case not artificial. The term is most often applied to the Earth or some parts of Earth.
The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
In prior work, we have pursued how tumor reactive monoclonal antibody (mAb), together with activators of innate immune cells, like NK cells, can augment antibody dependent cell-mediated cytot...
Molecular analyses of cancer biology have tended to segregate between a focus on nucleic acids – DNA, RNA and their modifications – and a focus on proteins and protein function. P...
Room air conditions are hypothermic, hypocapnic and hyperphysioxic from the cells’ point of view. Yet we stress cells with these uncontrolled conditions routinely. It is no wonder that...
With the advent of cost-effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-...
Early adverse exposures, such as maternal stress during pregnancy and child abuse, are thought to result in long-lasting consequences on neural circuit function and stress hormone regulation...
Proteomics offers a deeper understanding of the protein events influencing cellular and biological function. However, identifying key regulated proteins and their implicated signaling pathway...
The soil microbiome can produce, resist, or degrade antibiotics and even catabolize them. Resistance genes are widely distributed in the soil and may act as a reservoir for pathogen antibioti...
The bacterium Pantoea stewartii subsp. stewartii causes Stewart’s wilt disease in corn and serves as a model for other xylem-dwelling phytopathogens. P. stewartii is transmitted to plan...
The Alkek Center for Metagenomics and Microbiome Research (CMMR) at Baylor College of Medicine is pursuing numerous research and development efforts in the study of how the microbiome impacts...
Reducing the impact of infectious diseases is becoming increasingly vital as the prevalence of antimicrobial resistance (AMR) continues to rise, threatening the effective prevention and treat...
Horizontal gene transfer (HGT) has long been recognized as an important source of genetic diversity. In the clinical setting, HGT plays an important role in the spread of antibiotic resistanc...
Some bacteria can use an electrode as an electron donor for respiration, generating an electrical current in the process. We are trying to understand a bacterial community that uses electrici...
Next-generation DNA sequencing has opened new possibilities for microbial water quality monitoring, particularly for addressing emerging concerns like antibiotic resistance and opportunistic...
DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
With the advent of cost effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-...
Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementat...
Precision medicine and next-generation sequencing – Two terms characterized by a highly dynamic nature, strong innovations and a bright future. Both merged together will exert a decisiv...
The miniaturized total chemical analysis system has been successfully repurposed over the past twenty years or so for engineering cellular microenvironments which more faithfully mimic in viv...
Growing living human cells in vitro for basic research, drug discovery and reparative/regenerative medicine is challenged by the difficulty in developing methods for reproducibly and cost eff...
To provide insight on the utility and practicality of implementing a pharmacist-driven pharmacogenomics program in a community pharmacy or primary care setting and to provide a clinical updat...
The All of Us Research Program is a historic effort to gather data from one million or more people living in the United States to accelerate research and improve health. By taking into accoun...
In this presentation I will describe results from a family study designed to identify the genetic cause for familial clustering of several early onset cancers. Data from next generatio...
The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
In prior work, we have pursued how tumor reactive monoclonal antibody (mAb), together with activators of innate immune cells, like NK cells, can augment antibody dependent cell-mediated cytot...
Molecular analyses of cancer biology have tended to segregate between a focus on nucleic acids – DNA, RNA and their modifications – and a focus on proteins and protein function. P...
Room air conditions are hypothermic, hypocapnic and hyperphysioxic from the cells’ point of view. Yet we stress cells with these uncontrolled conditions routinely. It is no wonder that...
With the advent of cost-effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-...
Early adverse exposures, such as maternal stress during pregnancy and child abuse, are thought to result in long-lasting consequences on neural circuit function and stress hormone regulation...
Proteomics offers a deeper understanding of the protein events influencing cellular and biological function. However, identifying key regulated proteins and their implicated signaling pathway...
The soil microbiome can produce, resist, or degrade antibiotics and even catabolize them. Resistance genes are widely distributed in the soil and may act as a reservoir for pathogen antibioti...
The bacterium Pantoea stewartii subsp. stewartii causes Stewart’s wilt disease in corn and serves as a model for other xylem-dwelling phytopathogens. P. stewartii is transmitted to plan...
The Alkek Center for Metagenomics and Microbiome Research (CMMR) at Baylor College of Medicine is pursuing numerous research and development efforts in the study of how the microbiome impacts...
Reducing the impact of infectious diseases is becoming increasingly vital as the prevalence of antimicrobial resistance (AMR) continues to rise, threatening the effective prevention and treat...
Horizontal gene transfer (HGT) has long been recognized as an important source of genetic diversity. In the clinical setting, HGT plays an important role in the spread of antibiotic resistanc...
Some bacteria can use an electrode as an electron donor for respiration, generating an electrical current in the process. We are trying to understand a bacterial community that uses electrici...
Next-generation DNA sequencing has opened new possibilities for microbial water quality monitoring, particularly for addressing emerging concerns like antibiotic resistance and opportunistic...
DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
With the advent of cost effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-...
Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementat...
Precision medicine and next-generation sequencing – Two terms characterized by a highly dynamic nature, strong innovations and a bright future. Both merged together will exert a decisiv...
The miniaturized total chemical analysis system has been successfully repurposed over the past twenty years or so for engineering cellular microenvironments which more faithfully mimic in viv...
Growing living human cells in vitro for basic research, drug discovery and reparative/regenerative medicine is challenged by the difficulty in developing methods for reproducibly and cost eff...
To provide insight on the utility and practicality of implementing a pharmacist-driven pharmacogenomics program in a community pharmacy or primary care setting and to provide a clinical updat...
The All of Us Research Program is a historic effort to gather data from one million or more people living in the United States to accelerate research and improve health. By taking into accoun...
In this presentation I will describe results from a family study designed to identify the genetic cause for familial clustering of several early onset cancers. Data from next generatio...