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Enhancer
An Enhancer is a small section of DNA that can be used to bind protein together in order to increase the probability that the transcription of a specific gene will develop. There are hundreds of thousands of Enhancers that can be found in Prokaryotic and Eukaryotic cells within the human genome. Enhancers are cis-regulatory elements, which regulate the transcription of nearby genes and are an essential part of genetic regulatory networks.
FEB 13, 2019 | 7:30 AM
Digitalization has transformed virtually every industry, but it has been slow to gain traction within the preclinical phase of the drug development journey. Recent advances in digital vivariu...
JAN 31, 2019 | 7:30 AM
Prodrugs are harmless in their native state, as they are not targeted by human enzymes. But they can be converted into highly toxic compounds (the “drug”) by viral or bacterial en...
DEC 12, 2018 | 7:00 AM
DATE: December 12, 2018TIME: 07:00am PST, 10:00am EST Currently, the Cleveland Clinic Biorepository is an assembly of several biobanks tog...
DEC 05, 2018 | 8:00 PM
DATE: December 05, 2018TIME: 08:00 PSTWhat is desperately needed are methods to detect cells that cause metastasis–known as cancer stem cells (CSC), a subpopulation of...
DEC 05, 2018 | 9:00 AM
DATE: December 5, 2018TIME: 9:00AM PDTThe mouse is a critical, increasingly used model system in biomedical research and preclinical drug discovery. While technological advances en...
DEC 05, 2018 | 7:00 AM
DATE: December 05, 2018TIME: 07:00 PSTWhat is desperately needed are methods to detect cells that cause metastasis–known as cancer stem cells (CSC), a subpopulation of...
NOV 29, 2018 | 9:00 AM
DATE: November 29, 2018TIME: 9:00AM PDTAn overview of primary immune deficiency disorders (PID) and laboratory testing for PIDPrimary immune deficiencies (PIDs), oth...
NOV 28, 2018 | 7:00 AM
DATE: November 28, 2018TIME: 7:00AM PSTSingle-cell genomics enables a deep dive into the mechanisms responsible for health and disease, in areas from cancer biology to neurob...
NOV 20, 2018 | 1:00 AM
DATE: November 20, 2018’TIME: 3:00pm WET Today, hematology analyzers can collect vast amounts of data about cell characteristics, that subsequently improve...
NOV 14, 2018 | 10:30 AM
Decades of innovation have brought us into a new era of mass spectrometry with the design of Agilent’s revolutionary Triple Quadrupole LC/MS. Ultivo is packed full of the same power and...
NOV 01, 2018 | 12:00 AM
The success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on cancer cell and immune cell interaction, how cancer cells i...
NOV 01, 2018 | 12:00 AM
Alongside intense efforts to exploit T-cells as immunotherapies for cancer (e.g. checkpoint inhibitors, CAR-T, T-cell metabolism), researchers are increasingly considering other immune cell t...
OCT 25, 2018 | 7:30 AM
Alzheimer’s disease is becoming a public health crisis as the anticipated number of sufferers is expected to rise to 15 million in the next 30 years, at least in the US. These numbers a...
OCT 11, 2018 | 1:30 PM
Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
OCT 11, 2018 | 12:00 PM
Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between...
OCT 03, 2018 | 10:30 AM
There have been an increasing number of successful human gene therapy clinical trials, and in particular gene delivery vehicles or vectors based on the adeno-associated virus (AAV) have enabl...
