Discovery informatics encompasses a variety of technological and mathematical fields such as statistics, data programming, and machine learning. Using an interdisciplinary approach, Discovery informatics aims to generate novel ideas and technologies by integrating, analyzing, and understanding large and complex data sets.
Millions of individuals have been sequenced or genotyped and linked with medical records, providing an exciting opportunity for therapeutic target discovery. My lab has been using a resilienc...
We are at a time where traditionally risk-adverse health care systems and their IT architecture are confronted with the deluge of data at a massive scale and tremendous variability. In many H...
The advent of the microarray technology in 2000 has paved the way for advanced translational research methods that use molecular markers such as microRNA, proteins, metabolites and copy numbe...
In December 2012 the UK Prime Minister announced the 100,000 genomes project to introduce whole genome sequencing for treatment into the UK National Health Service (NHS) o...
A crucial part of providing animals for research is successful breeding. Still, in many mouse facilities breeding efficiency is complicated by problems with reproduction, such as pre-weaning...
Science continues to evolve at a rapid pace. Our understanding of laboratory animal behavior and welfare is also growing. The biomedical research community continues to receive criticisms fro...
Optimising experimental design needs a sound understanding of basic principles and a good appreciation of a range of designs and when to use them. More than ten years ago it was clear t...
Working with animals carries legal, scientific and ethical responsibilities. These responsibilities merge as we strive to humanely use the least number of animals necessary to provide t...
The environment has been found to be a major contributor to data variability and many aspects of the laboratory environment are stressful to rodents and do not accurately reflect the human ex...
Historically, rodent disease models have mainly used a single sex or did not stratify outcomes by sex when both sexes were studied. These experimental approaches were based on the assumption...
The reproducibility of animal studies is now critical to ensure that limited resources are used wisely and that efforts yield useable knowledge. At this time, IACUCs and other similar a...
The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is leading an initiative to improve the design and reporting of animal research. The ARRIVE (A...
The fate of all but a very few laboratory animals is to be killed at the end of their experimental lives. There is a moral responsibility to give the animals used in science a humane death by...
In the last decade the number of publications in zebrafish tripled, from 938 in 2005 to 2432 in 2015 (Pubmed database; keyword: “zebrafish” in Title/Abstract;...
Public, legal & ethical acceptability of animal research not only warrants respect for animal welfare & the 3Rs, but also that the perceived benefits can outweigh the pain, discomfort...
A number of elements come into the mix when trying to optimise experimental design. Among these are having clear objectives, setting up valid comparisons, knowing how to avoid bias during the...
Animal models have provided an important tool to help make the decision to take potential therapies from preclinical studies to humans. In the past several years, the strong reliance of the p...
Understanding systematic biases in primary research are important for appropriate interpretation of research and recognizing features of reproducible research. Systematic biases arise from th...
Surgerized animals play a crucial role in preclinical research aimed at drug and medical device discovery into treatments for humans. When implementing new in-house surgical models to perform...
The use of laboratory animals requires education and training of persons who are to design and/or perform animal experiments. It is essential for these persons to practice various procedures...
This presentation will discuss variables in rodent colony management that can affect colony breeding efficiency, rodent health, and factors that can modulate rodent models of disease. V...
Animal studies still play a crucial role in research aimed at improving human health care. When performing animal studies, the results and their interpretation are not always straightforward....
Animal studies performed on behalf of GlaxoSmithKline (GSK) are expected to uphold the core principles established by Corporate Policy 403, ‘Care, Welfare and Treatment of Animals by GS...
Millions of individuals have been sequenced or genotyped and linked with medical records, providing an exciting opportunity for therapeutic target discovery. My lab has been using a resilienc...
We are at a time where traditionally risk-adverse health care systems and their IT architecture are confronted with the deluge of data at a massive scale and tremendous variability. In many H...
The advent of the microarray technology in 2000 has paved the way for advanced translational research methods that use molecular markers such as microRNA, proteins, metabolites and copy numbe...
In December 2012 the UK Prime Minister announced the 100,000 genomes project to introduce whole genome sequencing for treatment into the UK National Health Service (NHS) o...
A crucial part of providing animals for research is successful breeding. Still, in many mouse facilities breeding efficiency is complicated by problems with reproduction, such as pre-weaning...
Science continues to evolve at a rapid pace. Our understanding of laboratory animal behavior and welfare is also growing. The biomedical research community continues to receive criticisms fro...
Optimising experimental design needs a sound understanding of basic principles and a good appreciation of a range of designs and when to use them. More than ten years ago it was clear t...
Working with animals carries legal, scientific and ethical responsibilities. These responsibilities merge as we strive to humanely use the least number of animals necessary to provide t...
The environment has been found to be a major contributor to data variability and many aspects of the laboratory environment are stressful to rodents and do not accurately reflect the human ex...
Historically, rodent disease models have mainly used a single sex or did not stratify outcomes by sex when both sexes were studied. These experimental approaches were based on the assumption...
The reproducibility of animal studies is now critical to ensure that limited resources are used wisely and that efforts yield useable knowledge. At this time, IACUCs and other similar a...
The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is leading an initiative to improve the design and reporting of animal research. The ARRIVE (A...
The fate of all but a very few laboratory animals is to be killed at the end of their experimental lives. There is a moral responsibility to give the animals used in science a humane death by...
In the last decade the number of publications in zebrafish tripled, from 938 in 2005 to 2432 in 2015 (Pubmed database; keyword: “zebrafish” in Title/Abstract;...
Public, legal & ethical acceptability of animal research not only warrants respect for animal welfare & the 3Rs, but also that the perceived benefits can outweigh the pain, discomfort...
A number of elements come into the mix when trying to optimise experimental design. Among these are having clear objectives, setting up valid comparisons, knowing how to avoid bias during the...
Animal models have provided an important tool to help make the decision to take potential therapies from preclinical studies to humans. In the past several years, the strong reliance of the p...
Understanding systematic biases in primary research are important for appropriate interpretation of research and recognizing features of reproducible research. Systematic biases arise from th...
Surgerized animals play a crucial role in preclinical research aimed at drug and medical device discovery into treatments for humans. When implementing new in-house surgical models to perform...
The use of laboratory animals requires education and training of persons who are to design and/or perform animal experiments. It is essential for these persons to practice various procedures...
This presentation will discuss variables in rodent colony management that can affect colony breeding efficiency, rodent health, and factors that can modulate rodent models of disease. V...
Animal studies still play a crucial role in research aimed at improving human health care. When performing animal studies, the results and their interpretation are not always straightforward....
Animal studies performed on behalf of GlaxoSmithKline (GSK) are expected to uphold the core principles established by Corporate Policy 403, ‘Care, Welfare and Treatment of Animals by GS...
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