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    Cytotoxicity

    Cytotoxicity: is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (Bitis arietans) or brown recluse spider (Loxosceles reclusa).

    Webinars

    • SEP 27, 2019 | 9:00 AM
      Investigating how Tpz-1 may be used as a novel therapeutic agent in the treatment of human hematologic cancers
      Investigating how Tpz-1 may be used as a novel therapeutic agent...
      DATE: September 27, 2019TIME: 9:00am PT, 12:00pm ET Thienopyrazole derivatives have recently emerged as effective antitumoral agents with kinase inhibitory activity. In this s...
      Speaker: Jessica Hess
      Sponsored By: Thermo Fisher Scientific/Gibco
      5
      SEP 24, 2019 | 8:00 AM
      Interrogating 3D spheroid versus 2D monolayer cell models in drug discovery using cell health microplate assays
      Interrogating 3D spheroid versus 2D monolayer cell models in drug...
      DATE: September 24, 2019TIME: 7:00am PDTHigh throughput screening (HTS) is an effective method for identifying putative active compounds for therapeutics. Assays that evaluate changes i...
      Speaker: Dr. Adyary Fallarero, Ph.D. Adjunct Professor/Docent in Pharmaceutical Biology , Dr. Leticia Montoya, Ph.D., Chemistry and Biochemistry
      Sponsored By: Thermo Fisher Scientific
      9
      APR 03, 2019 | 9:00 AM
      How to analyze/characterize your 3D culture
      How to analyze/characterize your 3D culture
      DATE:  April 3, 2019TIME:  9:00am PDT...
      Speaker: Chris Langsdorf
      Sponsored By: Thermo Fisher Scientific
      6
      OCT 10, 2018 | 12:00 PM
      Integrative Cancer Immunology and Novel Concepts of Cancer Evolution
      Integrative Cancer Immunology and Novel Concepts of Cancer Evolution
      To date the anatomic extent of tumor (TNM-classification) has been by far the most important factors to predict the prognosis of cancer patients. However, this classification provides limited...
      Speaker: Jerome Galon, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      OCT 10, 2018 | 9:00 AM
      Using Radiotherapy, Tumor-Reactive mAb and IL2 to Engage Innate and Adaptive Antitumor Immunity
      Using Radiotherapy, Tumor-Reactive mAb and IL2 to Engage Innate...
      In prior work, we have pursued how tumor reactive monoclonal antibody (mAb), together with activators of innate immune cells, like NK cells, can augment antibody dependent cell-mediated cytot...
      Speaker: Paul Sondel, MD, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      SEP 20, 2018 | 9:00 AM
      Defects in potassium channels contribute to reduced immune surveillance in cancers
      Defects in potassium channels contribute to reduced immune surveillance...
       DATE: September 20 2018TIME: 09:00am PDT, 12:00pm EDT Harnessing the immune system has emerged as a powerful therapeutic strategy in oncology. However, the limited...
      Speaker: Ameet Chimote, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      6
      SEP 11, 2018 | 7:00 AM
      Answering the Challenges of Cell Viability and Reporter Gene Assays Screening Cost and Quality
      Answering the Challenges of Cell Viability and Reporter Gene Assays...
      DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
      Speaker: Vincent Dupriez, PhD , Jeanine Hinterneder, PhD , Maria Kuzikov, MSc
      Sponsored By: Revvity
      5
      AUG 15, 2018 | 8:00 AM
      3D Spheroid Cell Models for Drug-Resistant Cancer Research
      3D Spheroid Cell Models for Drug-Resistant Cancer Research
      DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
      Speaker: Clarissa Willers, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      9 2
      JUN 28, 2018 | 8:00 AM
      Isolation of immune cells Straight From whole blood, buffy coat, LRSC, and Leukopak without density gradients
      Isolation of immune cells Straight From whole blood, buffy coat,...
      DATE: June 28, 2018TIME: 8:00AM PDTEnrichment of leukocytes from blood products like buffy coat, leukocyte reduction chambers (LRSC) or leukapheresis material can be time consuming...
      Speaker: Zhong Yu, PhD , Gregory Winkels, MS
      Sponsored By: Miltenyi Biotec
      13 2
      MAR 22, 2018 | 8:00 AM
      Simple and effective tools for antibody-drug conjugate screening and characterization
      Simple and effective tools for antibody-drug conjugate screening...
      Antibody drug conjugates (ADCs) represent a novel method to deliver a drug to diseased cell using the specific antigen-binding capability and internalization process. Antibodies that do not i...
      Speaker: Chris Langsdorf
      Presented at: Protein and Cell Analysis Education Series
      4
      NOV 09, 2017 | 9:00 AM
      Accelerating Immuno-Oncology Research with the PanCancer IO 360™ Gene Expression Panel, Advanced Data Analysis Service, and Signature Development
      Accelerating Immuno-Oncology Research with the PanCancer IO 360™...
      Transcriptional profiling of the tumor microenvironment can lead to insights about the interaction between the tumor and immune system. This facilitates investigation of immune evasion mechan...
      Speaker: Sarah Warren, PhD , Patrick Danaher, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
      Sponsored By: NanoString Technologies
      1
      NOV 01, 2017 | 12:00 PM
      WEBINAR: Simplified imaging for quantifying biological complexity of iPSC-derived cardiomyocytes and neurons
      WEBINAR: Simplified imaging for quantifying biological complexity...
      DATE: November 1, 2017TIME:  12:00 PM PT, 3:00 PM ETThere is a current focus in biology towards developing more complex and physiologically relevant in vitro assays and cell models...
      Speaker: Oksana Sirenko, PhD
      Sponsored By: Molecular Devices
      5
      OCT 12, 2017 | 12:00 PM
      Comprehensive genomic and transcriptomic analysis of acral melanoma: A path towards therapeutic development
      Comprehensive genomic and transcriptomic analysis of acral melanoma:...
      Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
      Speaker: Winnie Liang, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      1
      OCT 11, 2017 | 7:30 AM
      Keynote Presentation: Targeting Molecular Chaperones in Cancer: Lessons Learned from HSP90
      Keynote Presentation: Targeting Molecular Chaperones in Cancer:...
      The first small molecule inhibitor of the molecular chaperone Heat Shock Protein 90 (HSP90) was identified more than 20 years ago. Upon determination of the drug binding site and clarificatio...
      Speaker: Len Neckers, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      1
      JUN 22, 2017 | 7:00 AM
      WEBINAR: Live cell analysis - affordable and easy
      WEBINAR: Live cell analysis - affordable and easy
      DATE: June 22, 2017TIME: 7:00AM PDT, 10:00AM ETCell-based assays are a core research tool, offering an informative and cost-effective counterpart or alternative to in vivo and anim...
      Speaker: Christian Oberdanner, PhD , Cédric Muller, PhD
      Sponsored By: Tecan
      7
      FEB 23, 2017 | 12:00 PM
      Recent progress in cellular medicine with an eye to precision medicine
      Recent progress in cellular medicine with an eye to precision...
      Despite vast investment for decades in cancer research and development, cancer is still among the leading causes of death worldwide and its toll is expected to rise by about 70% over the next...
      Speaker: Giacinto Scoles, PhD
      Presented at: Precision Medicine Virtual Event Series 2017
      2
      JAN 17, 2017 | 8:00 AM
      Are your cells alive, dead, or just resting? Tips to assess viability and cytotoxicity (Part 1 of 3)
      Are your cells alive, dead, or just resting? Tips to assess viability...
      Quantification of cellular growth before and after an experiment is an essential technique for cell-based studies. Listen in as our scientific expert, Miriam Ferrer, Ph.D., reviews methods to...
      Speaker: Miriam Ferrer, PhD
      Presented at: Abcam virtual exhibition: support and products to advance your research
      4
      OCT 11, 2016 | 7:00 AM
      Cellular Applications for Image-based Cytometry on A Multimode Plate Reader
      Cellular Applications for Image-based Cytometry on A Multimode...
      Date: October 11th, 2016Time: 10:00AM EST, 4:00PM CEST, 3:00PM BST, 7:00AM PSTPlate readers first became available about 30 years ago and have become the workhorses of researc...
      Speaker: Frauke Haenel, PhD , Maria Kuzikov, MSc
      Sponsored By: Revvity
      8 1
      OCT 11, 2016 | 7:00 AM
      Two Dimensional Liquid Chromatography Applied to the Characterization of Monoclonal Antibodies and Antibody-Drug Conjugates
      Two Dimensional Liquid Chromatography Applied to the Characterization...
      DATE:  October 11, 2016 TIME:  7:00am PT, 10:00am ET Monoclonal antibodies (mAbs) have emerged as important therapeutics for the treatment of life-threatening diseases. The succ...
      Speaker: Koen Sandra, PhD
      Sponsored By: Agilent Genomics, Agilent Genomics
      5
      OCT 05, 2016 | 10:30 AM
      Immunotherapy of Cancer Using Genetically-Enhanced T Cells
      Immunotherapy of Cancer Using Genetically-Enhanced T Cells
      The immune system possesses significant cytotoxic potential. Stimulating natural immunity through vaccination has shown promising effects in some cancers; however, a number of barriers limit...
      Speaker: Michael Milone, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
      2
      NOV 12, 2015 | 9:00 AM
      Use of a CD200R Inhibitor to Overcome Central Nervous System Tumor Induced Immunosuppression
      Use of a CD200R Inhibitor to Overcome Central Nervous System Tumor...
      Cancer immunotherapy has demonstrated promising results. However, to date, researchers have failed to overcome the complex interplay between the immune system and the immune suppressive tumor...
      Speaker: Michael Olin
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2015
      2
      SEP 16, 2015 | 12:00 PM
      Developing Accurate Nanomedicines: The BIND Therapeutics Approach
      Developing Accurate Nanomedicines: The BIND Therapeutics Approach
      Nanotechnology, the engineering and manufacture of materials at the atomic and molecular scale, is used at BIND Therapeutics to develop novel Accurin™ nanomedicines that utilize cytotoxic age...
      Speaker: Hagop Youssoufian
      Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
      2
      MAY 26, 2015 | 6:00 AM
      Cell-Imaging and Luminescence Based Cytotoxicity Analysis using the EnSight Multimode Plate Reader
      Cell-Imaging and Luminescence Based Cytotoxicity Analysis using...
      Sign up here to watch this Webinar On DemandCytotoxicity remains one of the major causes of drug withdrawal and there is an urgent need for reliable and time-saving assay workflows. Cells exp...
      Speaker: Philip Gribbon , Frauke Haenel, PhD
      Sponsored By: Revvity
      24 1
      NOV 12, 2014 | 8:00 AM
      Hallmarks of cancer - Detect and quantify cell death signatures with high content imaging
      Hallmarks of cancer - Detect and quantify cell death signatures...
      Dr. Oliver Kepp will be presenting on:Immunogenic cell death fingerprinting utilizing a high-throughput screening approachThe strategy of immunogenic cell death fingerprinting has been design...
      Speaker: Oliver Kepp, PhD and Jayne A. Hesley
      Sponsored By: Molecular Devices, Molecular Devices
      33
    SEP 27, 2019 | 9:00 AM
    Investigating how Tpz-1 may be used as a novel therapeutic agent in the treatment of human hematologic cancers
    Investigating how Tpz-1 may be used as a novel therapeutic agent...
    DATE: September 27, 2019TIME: 9:00am PT, 12:00pm ET Thienopyrazole derivatives have recently emerged as effective antitumoral agents with kinase inhibitory activity. In this s...
    Speaker: Jessica Hess
    Sponsored By: Thermo Fisher Scientific/Gibco
    5
    SEP 24, 2019 | 8:00 AM
    Interrogating 3D spheroid versus 2D monolayer cell models in drug discovery using cell health microplate assays
    Interrogating 3D spheroid versus 2D monolayer cell models in drug...
    DATE: September 24, 2019TIME: 7:00am PDTHigh throughput screening (HTS) is an effective method for identifying putative active compounds for therapeutics. Assays that evaluate changes i...
    Speaker: Dr. Adyary Fallarero, Ph.D. Adjunct Professor/Docent in Pharmaceutical Biology , Dr. Leticia Montoya, Ph.D., Chemistry and Biochemistry
    Sponsored By: Thermo Fisher Scientific
    9
    APR 03, 2019 | 9:00 AM
    How to analyze/characterize your 3D culture
    How to analyze/characterize your 3D culture
    DATE:  April 3, 2019TIME:  9:00am PDT...
    Speaker: Chris Langsdorf
    Sponsored By: Thermo Fisher Scientific
    6
    OCT 10, 2018 | 12:00 PM
    Integrative Cancer Immunology and Novel Concepts of Cancer Evolution
    Integrative Cancer Immunology and Novel Concepts of Cancer Evolution
    To date the anatomic extent of tumor (TNM-classification) has been by far the most important factors to predict the prognosis of cancer patients. However, this classification provides limited...
    Speaker: Jerome Galon, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
    OCT 10, 2018 | 9:00 AM
    Using Radiotherapy, Tumor-Reactive mAb and IL2 to Engage Innate and Adaptive Antitumor Immunity
    Using Radiotherapy, Tumor-Reactive mAb and IL2 to Engage Innate...
    In prior work, we have pursued how tumor reactive monoclonal antibody (mAb), together with activators of innate immune cells, like NK cells, can augment antibody dependent cell-mediated cytot...
    Speaker: Paul Sondel, MD, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
     
     
  • SEP 20, 2018 | 9:00 AM
    Defects in potassium channels contribute to reduced immune surveillance in cancers
    Defects in potassium channels contribute to reduced immune surveillance...
     DATE: September 20 2018TIME: 09:00am PDT, 12:00pm EDT Harnessing the immune system has emerged as a powerful therapeutic strategy in oncology. However, the limited...
    Speaker: Ameet Chimote, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    6
    SEP 11, 2018 | 7:00 AM
    Answering the Challenges of Cell Viability and Reporter Gene Assays Screening Cost and Quality
    Answering the Challenges of Cell Viability and Reporter Gene Assays...
    DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
    Speaker: Vincent Dupriez, PhD , Jeanine Hinterneder, PhD , Maria Kuzikov, MSc
    Sponsored By: Revvity
    5
    AUG 15, 2018 | 8:00 AM
    3D Spheroid Cell Models for Drug-Resistant Cancer Research
    3D Spheroid Cell Models for Drug-Resistant Cancer Research
    DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
    Speaker: Clarissa Willers, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    9 2
    JUN 28, 2018 | 8:00 AM
    Isolation of immune cells Straight From whole blood, buffy coat, LRSC, and Leukopak without density gradients
    Isolation of immune cells Straight From whole blood, buffy coat,...
    DATE: June 28, 2018TIME: 8:00AM PDTEnrichment of leukocytes from blood products like buffy coat, leukocyte reduction chambers (LRSC) or leukapheresis material can be time consuming...
    Speaker: Zhong Yu, PhD , Gregory Winkels, MS
    Sponsored By: Miltenyi Biotec
    13 2
    MAR 22, 2018 | 8:00 AM
    Simple and effective tools for antibody-drug conjugate screening and characterization
    Simple and effective tools for antibody-drug conjugate screening...
    Antibody drug conjugates (ADCs) represent a novel method to deliver a drug to diseased cell using the specific antigen-binding capability and internalization process. Antibodies that do not i...
    Speaker: Chris Langsdorf
    Presented at: Protein and Cell Analysis Education Series
    4
     
     
  • NOV 09, 2017 | 9:00 AM
    Accelerating Immuno-Oncology Research with the PanCancer IO 360™ Gene Expression Panel, Advanced Data Analysis Service, and Signature Development
    Accelerating Immuno-Oncology Research with the PanCancer IO 360™...
    Transcriptional profiling of the tumor microenvironment can lead to insights about the interaction between the tumor and immune system. This facilitates investigation of immune evasion mechan...
    Speaker: Sarah Warren, PhD , Patrick Danaher, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
    Sponsored By: NanoString Technologies
    1
    NOV 01, 2017 | 12:00 PM
    WEBINAR: Simplified imaging for quantifying biological complexity of iPSC-derived cardiomyocytes and neurons
    WEBINAR: Simplified imaging for quantifying biological complexity...
    DATE: November 1, 2017TIME:  12:00 PM PT, 3:00 PM ETThere is a current focus in biology towards developing more complex and physiologically relevant in vitro assays and cell models...
    Speaker: Oksana Sirenko, PhD
    Sponsored By: Molecular Devices
    5
    OCT 12, 2017 | 12:00 PM
    Comprehensive genomic and transcriptomic analysis of acral melanoma: A path towards therapeutic development
    Comprehensive genomic and transcriptomic analysis of acral melanoma:...
    Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
    Speaker: Winnie Liang, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    1
    OCT 11, 2017 | 7:30 AM
    Keynote Presentation: Targeting Molecular Chaperones in Cancer: Lessons Learned from HSP90
    Keynote Presentation: Targeting Molecular Chaperones in Cancer:...
    The first small molecule inhibitor of the molecular chaperone Heat Shock Protein 90 (HSP90) was identified more than 20 years ago. Upon determination of the drug binding site and clarificatio...
    Speaker: Len Neckers, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    1
    JUN 22, 2017 | 7:00 AM
    WEBINAR: Live cell analysis - affordable and easy
    WEBINAR: Live cell analysis - affordable and easy
    DATE: June 22, 2017TIME: 7:00AM PDT, 10:00AM ETCell-based assays are a core research tool, offering an informative and cost-effective counterpart or alternative to in vivo and anim...
    Speaker: Christian Oberdanner, PhD , Cédric Muller, PhD
    Sponsored By: Tecan
    7
     
     
  • FEB 23, 2017 | 12:00 PM
    Recent progress in cellular medicine with an eye to precision medicine
    Recent progress in cellular medicine with an eye to precision...
    Despite vast investment for decades in cancer research and development, cancer is still among the leading causes of death worldwide and its toll is expected to rise by about 70% over the next...
    Speaker: Giacinto Scoles, PhD
    Presented at: Precision Medicine Virtual Event Series 2017
    2
    JAN 17, 2017 | 8:00 AM
    Are your cells alive, dead, or just resting? Tips to assess viability and cytotoxicity (Part 1 of 3)
    Are your cells alive, dead, or just resting? Tips to assess viability...
    Quantification of cellular growth before and after an experiment is an essential technique for cell-based studies. Listen in as our scientific expert, Miriam Ferrer, Ph.D., reviews methods to...
    Speaker: Miriam Ferrer, PhD
    Presented at: Abcam virtual exhibition: support and products to advance your research
    4
    OCT 11, 2016 | 7:00 AM
    Cellular Applications for Image-based Cytometry on A Multimode Plate Reader
    Cellular Applications for Image-based Cytometry on A Multimode...
    Date: October 11th, 2016Time: 10:00AM EST, 4:00PM CEST, 3:00PM BST, 7:00AM PSTPlate readers first became available about 30 years ago and have become the workhorses of researc...
    Speaker: Frauke Haenel, PhD , Maria Kuzikov, MSc
    Sponsored By: Revvity
    8 1
    OCT 11, 2016 | 7:00 AM
    Two Dimensional Liquid Chromatography Applied to the Characterization of Monoclonal Antibodies and Antibody-Drug Conjugates
    Two Dimensional Liquid Chromatography Applied to the Characterization...
    DATE:  October 11, 2016 TIME:  7:00am PT, 10:00am ET Monoclonal antibodies (mAbs) have emerged as important therapeutics for the treatment of life-threatening diseases. The succ...
    Speaker: Koen Sandra, PhD
    Sponsored By: Agilent Genomics, Agilent Genomics
    5
    OCT 05, 2016 | 10:30 AM
    Immunotherapy of Cancer Using Genetically-Enhanced T Cells
    Immunotherapy of Cancer Using Genetically-Enhanced T Cells
    The immune system possesses significant cytotoxic potential. Stimulating natural immunity through vaccination has shown promising effects in some cancers; however, a number of barriers limit...
    Speaker: Michael Milone, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
    2
     
     
  • NOV 12, 2015 | 9:00 AM
    Use of a CD200R Inhibitor to Overcome Central Nervous System Tumor Induced Immunosuppression
    Use of a CD200R Inhibitor to Overcome Central Nervous System Tumor...
    Cancer immunotherapy has demonstrated promising results. However, to date, researchers have failed to overcome the complex interplay between the immune system and the immune suppressive tumor...
    Speaker: Michael Olin
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2015
    2
    SEP 16, 2015 | 12:00 PM
    Developing Accurate Nanomedicines: The BIND Therapeutics Approach
    Developing Accurate Nanomedicines: The BIND Therapeutics Approach
    Nanotechnology, the engineering and manufacture of materials at the atomic and molecular scale, is used at BIND Therapeutics to develop novel Accurin™ nanomedicines that utilize cytotoxic age...
    Speaker: Hagop Youssoufian
    Presented at: C&EN's Virtual Symposium: Advances in Drug Discovery and Development
    2
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