Computational Neuroscience: is a branch of neuroscience that employs mathematical models, theoretical analysis and abstractions of the brain to understand principles that govern the development, structure, physiology and cognitive abilities of the nervous system.
Working memory (the ability to hold some information in mind for a few seconds, and to manipulate that information) and decision-making (committing to one out of multiple possible choices) a...
Neurodegenerative disease research can be considerably accelerated by using fibrillar or oligomeric constructs of prion-like proteins in in vitro or in vivo studies. These exist in a variety...
Episodic memories are essential for human cognition, but the underlying neural mechanisms remain poorly understood. We utilize the opportunity to record in-vivo from human single neurons sim...
Learning is often an emotional process. Emotional stimuli with different valences, such as threat and reward, can transform an otherwise neutral sensory input into one that can trigger disti...
Approximately 300,000 people in the United States have a spinal cord injury with many of these individuals experiencing permanent motor and sensory deficits. For individuals with cervical sp...
Brain machine interfaces (BMIs) aim to help patients with paralysis to use their recorded brain activity to control assistive devices. BMI research requires the collaboration of neuroscienti...
Mechanistic understanding of neural systems is daunting to achieve in large part due to the heterogeneity of the neuronal elements in both form and function and the complexity of the circuit...
The neural basis of simple rhythmic and reflexive behaviors such as swimming and gill withdrawal have been successfully studied in nudibranchs and other gastropod molluscs because the brains...
The public health burden of Treatment Resistant Depression (TRD) has prompted clinical trials of deep brain stimulation (DBS) that have, unfortunately, produced inconsistent outcomes. Potent...
The accumulation of neurotoxic amyloid beta peptides and/or neurofibrillary tangle formation are key pathological hallmarks of neurodegenerative diseases including but not limited to Alzheim...
The US Brain Research through Advancing Innovative Neurotechnologies is a research program focused on building fundamental knowledge of how brain circuits process information to enable human...
Although neuroscience has provided a great deal of information about how neurons work, the fundamental question of how neurons function together in a network to produce cognition has been di...
Autosomal dominant missense mutations that hyperactivate the LRRK2 protein kinase are a common cause of inherited Parkinson’s disease and therapeutic efficacy of LRRK2 inhibitors is be...
Brain function is remarkably reliable despite the imprecise performance of neurons, and the continuous perturbations caused by aging, disease or injury. How does the brain succeed in produci...
Miltenyi Biotec offers a variety of neuroscience and immunology workflows that cover all steps from sample preparation and cell isolation to cell culture and flow cytometry. Discover the bre...
We present here a framework to generate a realistic multiscale circuit model of the larval zebrafish brain – the multiscale virtual fish (MVF). The model will be based on algorithms in...
The locomotion of humans and other animals requires a seamless flow of information from sensory modalities all the way to the motor periphery. As such, locomotion is an excellent system for...
Centhaquine (previously used names, centhaquin and PMZ-2010; International Non-proprietary Name (INN) recently approved by WHO is centhaquine) is being developed by us as a first-in-class re...
Misfolded and accumulated neurodegenerative disease associated proteins (NDAPs, such as tau and alpha-synuclein) represent the major pathological hallmark in Alzheimer’s and Parkinson&...
Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the av...
Chaperone networks are dysregulated with aging, but whether compromised Hsp70/Hsp90 chaperone function disturbs neuronal resilience is unknown. Stress‐inducible phosphoprotein 1 (STI1; STIP1...
Recent technological advancements in neuroprosthetics allow for wireless recording and stimulation of brain activity in freely moving human participants. At the same time, advancements in vi...
Normal behavior in any moving animal, including humans, relies on communication between motor systems that control movements, and the sensory systems we use to guide these actions. A critica...
The study of biological function in intact organisms and the development of targeted cellular therapeutics necessitate methods to image and control cellular function in vivo. Technologies su...
Working memory (the ability to hold some information in mind for a few seconds, and to manipulate that information) and decision-making (committing to one out of multiple possible choices) a...
Neurodegenerative disease research can be considerably accelerated by using fibrillar or oligomeric constructs of prion-like proteins in in vitro or in vivo studies. These exist in a variety...
Episodic memories are essential for human cognition, but the underlying neural mechanisms remain poorly understood. We utilize the opportunity to record in-vivo from human single neurons sim...
Learning is often an emotional process. Emotional stimuli with different valences, such as threat and reward, can transform an otherwise neutral sensory input into one that can trigger disti...
Approximately 300,000 people in the United States have a spinal cord injury with many of these individuals experiencing permanent motor and sensory deficits. For individuals with cervical sp...
Brain machine interfaces (BMIs) aim to help patients with paralysis to use their recorded brain activity to control assistive devices. BMI research requires the collaboration of neuroscienti...
Mechanistic understanding of neural systems is daunting to achieve in large part due to the heterogeneity of the neuronal elements in both form and function and the complexity of the circuit...
The neural basis of simple rhythmic and reflexive behaviors such as swimming and gill withdrawal have been successfully studied in nudibranchs and other gastropod molluscs because the brains...
The public health burden of Treatment Resistant Depression (TRD) has prompted clinical trials of deep brain stimulation (DBS) that have, unfortunately, produced inconsistent outcomes. Potent...
The accumulation of neurotoxic amyloid beta peptides and/or neurofibrillary tangle formation are key pathological hallmarks of neurodegenerative diseases including but not limited to Alzheim...
The US Brain Research through Advancing Innovative Neurotechnologies is a research program focused on building fundamental knowledge of how brain circuits process information to enable human...
Although neuroscience has provided a great deal of information about how neurons work, the fundamental question of how neurons function together in a network to produce cognition has been di...
Autosomal dominant missense mutations that hyperactivate the LRRK2 protein kinase are a common cause of inherited Parkinson’s disease and therapeutic efficacy of LRRK2 inhibitors is be...
Brain function is remarkably reliable despite the imprecise performance of neurons, and the continuous perturbations caused by aging, disease or injury. How does the brain succeed in produci...
Miltenyi Biotec offers a variety of neuroscience and immunology workflows that cover all steps from sample preparation and cell isolation to cell culture and flow cytometry. Discover the bre...
We present here a framework to generate a realistic multiscale circuit model of the larval zebrafish brain – the multiscale virtual fish (MVF). The model will be based on algorithms in...
The locomotion of humans and other animals requires a seamless flow of information from sensory modalities all the way to the motor periphery. As such, locomotion is an excellent system for...
Centhaquine (previously used names, centhaquin and PMZ-2010; International Non-proprietary Name (INN) recently approved by WHO is centhaquine) is being developed by us as a first-in-class re...
Misfolded and accumulated neurodegenerative disease associated proteins (NDAPs, such as tau and alpha-synuclein) represent the major pathological hallmark in Alzheimer’s and Parkinson&...
Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the av...
Chaperone networks are dysregulated with aging, but whether compromised Hsp70/Hsp90 chaperone function disturbs neuronal resilience is unknown. Stress‐inducible phosphoprotein 1 (STI1; STIP1...
Recent technological advancements in neuroprosthetics allow for wireless recording and stimulation of brain activity in freely moving human participants. At the same time, advancements in vi...
Normal behavior in any moving animal, including humans, relies on communication between motor systems that control movements, and the sensory systems we use to guide these actions. A critica...
The study of biological function in intact organisms and the development of targeted cellular therapeutics necessitate methods to image and control cellular function in vivo. Technologies su...
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