Cells carry out specialized functions throughout the body and each cell type functions distinctly from other cell types. Some cellular functions include transporting nutrients throughout the body and producing energy. One specialized cell is muscle cells which function to create a force that moves parts of the body. Another example are bone cells, whose functions include protecting internal organs from damage and storing minerals such as calcium.
Date: June 16, 2021 Time: 8:00am PDT The MACSima™ Imaging Platform is the only complete solution for ultrahigh-content imaging of hundreds of markers, allowing you to understand the tu...
Date: June 15, 2021 Time: 10:00am (PDT), 1:00pm (EDT) SPRm (Surface Plasmon Resonance Microscopy) is a novel technology that enables label-free and real-time binding affinity and kinetics of...
Date: June 15, 2021 Time: 9:00am PDT HbA1c is routinely used in the clinical laboratory to diagnose and monitor diabetes mellitus. Many methods have been standardized to provide precise and...
DATE: June 03, 2021 TIME: 7:00am PDT Dr. Anne Kornreich will discuss her career journey in laboratory medicine that began with hematology and progressed to a leadership role through addition...
Cells in their natural environment are surrounded by a complex extracellular matrix that provides structure and functional cues to the surrounding cells. Hydrogels can be used to approximate...
PD-L1 is a key inhibitor of T cell activation that is often over-expressed in cancer to escape immune surveillance and promote tumor progression. Blocking antibodies against PD-L1 or its rec...
Gene editing experts within MilliporeSigma’s Cell Design Studio™ provide premier custom cell line engineering services to create and deliver unique cell-based assays tailored for...
Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy (CART19) occurs in 10% to 20% of patients with acute lymphoblastic leukemia (ALL); however, the mechanisms of thi...
Learning Objectives: 1. Understand how the outcome of PD-1 blockade is a summation of increased Teffector activity and increased Treg suppressive activity 2. Explain how PD-1 blockade leads...
Learning Objectives: 1. Learn about why Luminex’s xMAP bead-based technology is the gold-standard in multiplexing, including how xMAP emerged as the leading multiplexing platform for l...
Chimeric antigen receptor (CAR) T cells have demonstrated significant success in treating relapsed or treatment-refractory hematologic malignancies in the clinic, inducing remissions in 70-9...
Despite the promising results with current approved immunotherapies, all patients do not have the same level of response, and recent efforts have focused on understanding and avoiding immuno...
Learning Objectives: 1. Define “universal CARs” and describe their mechanism of action. 2. Explain current challenges in CAR T cell therapy. 3. Describe potential benefits and ch...
Learning Objectives: 1. Define the impact of PD-L1 expressed on non-tumor, non-hematopoietic cells in T cell-mediated tumor control 2. Reveal the contribution of IFNg signaling in dermal lym...
Progress developing immune-based treatments to treat the highly lethal pancreatic ductal adenocarcinoma (PDA) has lagged behind other cancer types. This may be due, in part, to a fibroinflam...
Immune checkpoint therapy (ICT) is a front-line treatment for lung cancer; however, low mutational burden and ‘non-T cell inflamed’ signatures predict poor responses to ICT in ~5...
Rhabdomyosarcoma (RMS) is a soft tissue cancer commonly arising in muscle and is the most common soft tissue cancer in children. Patients with metastatic RMS have a poor prognosis that has n...
Date: May 27, 2021 Time: 8:00am (PDT), 11:00am (EDT) With social distancing measures still enforced in large parts of the world, many researchers must minimize time in the lab where they may...
Date: May 26, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors but is challenged in that only a minority of patie...
Date: May 25, 2021 Time: 8:00am (PDT) Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, bu...
Date: May 19, 2021 Time: 8:00am PDT Cellular cryo-electron tomography is a high-resolution technique that enables imaging of the molecular machinery of a cell at close-to-native conditions....
Traditional hybridoma and phage display methods have failed to yield therapeutic antibodies against difficult targets like most GPCRs and ion channels. This presentation will introduce Berke...
For the past years, my laboratory has been working on microfluidic devices to enable the analysis of single cells. Our technology of choice has been droplet microfluidics that encapsulates s...
Date: June 16, 2021 Time: 8:00am PDT The MACSima™ Imaging Platform is the only complete solution for ultrahigh-content imaging of hundreds of markers, allowing you to understand the tu...
Date: June 15, 2021 Time: 10:00am (PDT), 1:00pm (EDT) SPRm (Surface Plasmon Resonance Microscopy) is a novel technology that enables label-free and real-time binding affinity and kinetics of...
Date: June 15, 2021 Time: 9:00am PDT HbA1c is routinely used in the clinical laboratory to diagnose and monitor diabetes mellitus. Many methods have been standardized to provide precise and...
DATE: June 03, 2021 TIME: 7:00am PDT Dr. Anne Kornreich will discuss her career journey in laboratory medicine that began with hematology and progressed to a leadership role through addition...
Cells in their natural environment are surrounded by a complex extracellular matrix that provides structure and functional cues to the surrounding cells. Hydrogels can be used to approximate...
PD-L1 is a key inhibitor of T cell activation that is often over-expressed in cancer to escape immune surveillance and promote tumor progression. Blocking antibodies against PD-L1 or its rec...
Gene editing experts within MilliporeSigma’s Cell Design Studio™ provide premier custom cell line engineering services to create and deliver unique cell-based assays tailored for...
Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy (CART19) occurs in 10% to 20% of patients with acute lymphoblastic leukemia (ALL); however, the mechanisms of thi...
Learning Objectives: 1. Understand how the outcome of PD-1 blockade is a summation of increased Teffector activity and increased Treg suppressive activity 2. Explain how PD-1 blockade leads...
Learning Objectives: 1. Learn about why Luminex’s xMAP bead-based technology is the gold-standard in multiplexing, including how xMAP emerged as the leading multiplexing platform for l...
Chimeric antigen receptor (CAR) T cells have demonstrated significant success in treating relapsed or treatment-refractory hematologic malignancies in the clinic, inducing remissions in 70-9...
Despite the promising results with current approved immunotherapies, all patients do not have the same level of response, and recent efforts have focused on understanding and avoiding immuno...
Learning Objectives: 1. Define “universal CARs” and describe their mechanism of action. 2. Explain current challenges in CAR T cell therapy. 3. Describe potential benefits and ch...
Learning Objectives: 1. Define the impact of PD-L1 expressed on non-tumor, non-hematopoietic cells in T cell-mediated tumor control 2. Reveal the contribution of IFNg signaling in dermal lym...
Progress developing immune-based treatments to treat the highly lethal pancreatic ductal adenocarcinoma (PDA) has lagged behind other cancer types. This may be due, in part, to a fibroinflam...
Immune checkpoint therapy (ICT) is a front-line treatment for lung cancer; however, low mutational burden and ‘non-T cell inflamed’ signatures predict poor responses to ICT in ~5...
Rhabdomyosarcoma (RMS) is a soft tissue cancer commonly arising in muscle and is the most common soft tissue cancer in children. Patients with metastatic RMS have a poor prognosis that has n...
Date: May 27, 2021 Time: 8:00am (PDT), 11:00am (EDT) With social distancing measures still enforced in large parts of the world, many researchers must minimize time in the lab where they may...
Date: May 26, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors but is challenged in that only a minority of patie...
Date: May 25, 2021 Time: 8:00am (PDT) Reliable expression of recombinant proteins in human, CHO, or insect cells is essential for many aspects of biomedical research and drug development, bu...
Date: May 19, 2021 Time: 8:00am PDT Cellular cryo-electron tomography is a high-resolution technique that enables imaging of the molecular machinery of a cell at close-to-native conditions....
Traditional hybridoma and phage display methods have failed to yield therapeutic antibodies against difficult targets like most GPCRs and ion channels. This presentation will introduce Berke...
For the past years, my laboratory has been working on microfluidic devices to enable the analysis of single cells. Our technology of choice has been droplet microfluidics that encapsulates s...
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