Lipoprotein: Lipoproteins are complex proteins that help to transport cholesterol throughout the body. Lipoproteins can be divided in seven distinct categories based on size and composition. Some well-known lipoproteins included low-density lipoproteins (LDL; also known as "bad" cholesterol) and high-density lipoproteins (HDL; also known as "good" cholesterol). LDL can build up within the body and collect on arteries which increases the risk for heart disease and stroke. On the contrary, HDL absorbs cholesterol and carries it to the liver where it is degraded.
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Most FDA-approved therapeutic drugs target transmembrane proteins, yet the development of monoclonal antibodies for multi-transmembrane protein targets has been limited. Despite the abundanc...
In 1910, Harrison published the first report of frog embryonic sympathetic ganglia grown in hanging drops of lymph for a few days, where single neurons extended nerve fibers with complex gro...
Extracellular ligands bind to receptors on the cell surface leading to receptor internalization. Once internalized into small vesicles, the vesicles fuse with an organelle known as the sorti...
MicroRNA(miRNA) are short non-coding single stranded RNA molecules that regulate gene expression at the post transcriptional level. They are known to play a critical role in multiple biologi...
The advent of precision medicine largely depends on the creation of precise and accurate predictive tools. While most late-onset diseases are moderately to highly heritable, using genetic inf...