mouse monoclonal IgG1; IL-8RB Antibody (E-2) is an IgG1 λ mouse monoclonal IL-8RB antibody (also designated C-X-C motif chemokine receptor 2 antibody, intestinal microvascular endothelial cell angiogenic signaling related antibody, Interleukin 8 receptor, beta antibody, IL8R2 antibody, IL8RB antibody, cluster of differentiation 182 antibody, or CD182 antibody) that detects the IL-8RB protein of human origin by WB, IP, IF, IHC(P) and FCM. IL-8RB Antibody (E-2) is available as both the non-conjugated anti-IL-8RB antibody form, as well as multiple conjugated forms of anti-IL-8RB antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. IL-8 has been shown to function as a potent neutrophil chemostatic and activating peptide and is an important mediator of inflammatory diseases. Two distinct human IL-8 receptors, designated IL-8RA and IL-8RB, have been characterized. Both are expressed at a high level on neutrophils, and to a lesser extent on monocytes and myeloid cell lines. In addition, the IL-8RA subunit is expressed in T cells such as the Jurkat cell line. Both IL-8Rs are members of the seven transmembrane domain rhodopsin superfamily of receptors and as such, couple G proteins for signal transduction. The two receptors share 77% amino acid identity. IL-8RA exhibits high affinity binding for IL-8 and low affinity MGSA binding, whereas IL-8RB has high affinity binding for both IL-8 and MGSA.