mouse monoclonal IgG1; IL-8RA Antibody (B-1) is an IgG1 κ mouse monoclonal IL-8RA antibody (also designated C-X-C motif chemokine receptor 1 antibody, spinal cord oligodendrocyte maturation related antibody, Interleukin 8 (IL8) G-protein coupled receptor antibody, IL8R1 antibody, IL8RA antibody, cluster of differentiation 181 antibody, or CD181 antibody) that detects the IL-8RA protein of human and hamster origin by WB, IP, IF, IHC(P) and ELISA. IL-8RA Antibody (B-1) is available as both the non-conjugated anti-IL-8RA antibody form, as well as multiple conjugated forms of anti-IL-8RA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. IL-8 has been shown to function as a potent neutrophil chemostatic and activating peptide and is an important mediator of inflammatory diseases. Two distinct human IL-8 receptors, designated IL-8RA and IL-8RB have been characterized. Both are expressed at a high level on neutrophils and to a lesser extent on monocytes and myeloid cell lines. In addition, the IL-8RA subunit is expressed in T cells such as the Jurkat cell line. Both IL-8Rs are members of the seven-transmembrane domain rhodopsin superfamily of receptors and as such, couple G proteins for signal transduction. The two receptors share 77% amino acid identity. IL-8RA exhibits high-affinity binding for IL-8 and low-affinity MGSA binding, whereas IL-8RB has high-affinity binding for both IL-8 and MGSA.