mouse monoclonal IgG2a; Ras GAP Antibody (B4F8) is an IgG2a κ mouse monoclonal Ras GAP antibody (also designated RAS P21 Protein Activator 1 antibody, P120GAP antibody, GAP antibody, P120 RAS GTPase Activating Protein antibody, Ras GTPase-Activating Protein 1 antibody, RASA antibody, P120 antibody, Triphosphatase-Activating Protein antibody, GTPase-Activating Protein antibody, Ras P21 Protein Activator antibody, CMAVM1 antibody, or RasGAP antibody) that detects the Ras GAP protein of mouse, rat and human origin by WB, IP, IF, FCM and ELISA. Ras GAP Antibody (B4F8) is available as both the non-conjugated anti-Ras GAP antibody form, as well as multiple conjugated forms of anti-Ras GAP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins. p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state. Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations. Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold. The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity, and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).