mouse monoclonal IgM; CDw75/ST6GAL1 Antibody (LN-1) is an IgM mouse monoclonal CDw75/ST6GAL1 antibody (also designated CDw75 antibody) that detects the ST6GAL1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. CDw75/ST6GAL1 Antibody (LN-1) is available as both the non-conjugated anti-CDw75/ST6GAL1 antibody form, as well as multiple conjugated forms of anti-CDw75/ST6GAL1 antibody, including PE, FITC. Modification of cell surface glycoprotein and glycolipid oligosaccharides is thought to play a role in tumorigenesis and metastasis. Sialyltransferases catalyze the incorporation of sialic acid into the carbohydrate chains present on glycoproteins and function in intracellular terminal glycosylation pathways. The expression of one such sialyltransferase, CD75, (also known as ST6GAL1), leads to the appearance of the cell surface antigens CD76, HB-6 and CDw75. Expressed in the golgi apparatus and secreted into the extracellular fluid, ST6GAL1 is a type II membrane protein that is involved in generating sialylated antigens that function as cell-surface carbohydrate determinants. One such antigen, CDw75 (also known as CD75s or CD75-sialyated), is formed via the catalytic transfer of a sialic acid residue from CD75 to a cell surface galactose-containing carbohydrate acceptor. While CD75 functions in cells throughout the body, CDw75 is found primarily on B and T cells and may be upregulated in B-cell leukemias, suggesting a possible role for CDw75 in carcinogenesis.