mouse monoclonal IgG1; E2A Antibody (Yae) is an IgG1 κ mouse monoclonal E2A antibody (also designated E2A antibody or TCF3 antibody) that detects ITF-1, and E2A isoforms E12 and E47 of mouse, rat and human origin by WB, IP and IF. E2A Antibody (Yae) is available as the non-conjugated anti-E2A antibody form, as well as multiple conjugated forms of anti-E2A antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Transcription factor 3 (E47, E12, E2A immunoglobulin enhancer binding factors E12/E47, E2A, ITF1, TCF3) influences gene expression during B cell maturation.Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 andherculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and hetero-oligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage-specific gene expression.