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Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.
Santa Cruz Biotechnology
Paip1 (F-6) | Santa Cruz Biotechnology
mouse monoclonal IgG1; Paip, for PABP-interacting protein, binds to the polyadenylate-binding protein (PABP), which in yeasts and plants has been shown to bind to the eukaryotic initiation factor component eIF4G. There are two Paip proteins called Paip1 and Paip2. Paip1 stimulates translation, and Paip2, which competes with Paip1 for binding to PABP, represses translation. Paip2 decreases the affinity of PABP for polyadenylate RNA, and disrupts the repeating structure of poly(A) ribonucleoprotein. Paip1 contains an eIF4A-binding region and a proline-rich N terminus. Overexpression of Paip1 in COS-7 cells stimulates translation, perhaps by providing a physical link between the mRNA termini. The human Paip1 gene encodes a 480 amino acid protein.
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