mouse monoclonal IgG2b; TTI1 Antibody (B-1) is an IgG2b κ mouse monoclonal TTI1 antibody (also designated TTI1 antibody) that detects the TTI1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. TTI1 Antibody (B-1) is available as both the non-conjugated anti-TTI1 antibody form, as well as multiple conjugated forms of anti-TTI1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TTI1 (TELO2-interacting protein 1 homolog), also known as SMG10, is a 1,089 amino acid protein that is widely expressed and belongs to the TTI1 family. TTI1 functions as a regulator of the DNA damage response (DDR) and is a component of the TTT complex, which is necessary for the stabilization of protein levels of the phosphatidylinositol 3-kinase (PIKK) family. The TTT complex is a part of the cellular resistance to DNA damage stresses such as ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). In combination with the TTT complex and HSP90, TTI1 may play a role in the proper folding of newly synthesized PIKKs. TTI1 also is involved in the assembly of mTORC1 and mTORC2 complexes, as well as their stabilization and maintenance. TTI1 is post-tanslationally modified at serine 459 and the gene encoding this protein maps to human chromosome 20.