mouse monoclonal IgG2a; VPS16 Antibody (2F10) is an IgG2a κ mouse monoclonal VPS16 antibody that detects the VPS16 protein of human origin by WB, IP, IF and ELISA. VPS16 Antibody (2F10) is available as the non-conjugated anti-VPS16 antibody. Vacuolar sorting proteins (VPSs) are required for proper trafficking of endocytic and biosynthetic proteins to the vacuole and play an important role in the budding process of cells. The VPS proteins are highly conserved in mammal, yeast and Drosophila. VPS16 (vacuolar protein sorting 16) is a 839 amino acid protein that localizes to the cytoplasmic side of membranes and is ubiquitously expressed. Existing as a component of the Class C VPS protein complex along with VPS11, VPS18 and VPS33, VPS16 is thought to play a role in membrane docking/fusion reactions of late endosomes/lysosomes and may also participate in vesicle-mediated protein trafficking to lysosomal compartments. Mutations in the gene encoding VPS16 may disrupt trafficking to lysosomes and lysosome-related organelles that can potentially cause multiple diseases, including Hermansky-Pudlak syndrome.