Santa Cruz Biotechnology

IgA1 (H-11) | Santa Cruz Biotechnology

mouse monoclonal IgG1; IgA1 Antibody (H-11) is an IgG1 κ mouse monoclonal IgA1 antibody that detects IgA1 of human origin by WB, IP, IF, IHC(P) and ELISA. IgA1 Antibody (H-11) is available as the non-conjugated anti-IgA1 antibody form, as well as multiple conjugated forms of anti-IgA1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. The IgA heavy chain is an α-chain, and the light chains are either κ- or λ- chains. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces.

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ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.