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Long read Structural Variation calling remains a challenging but highly accurate way to identify complex genomic alterations. To address this challenge, we developed Sniffles2, a successor t...
Infectious disease monitoring on Oxford Nanopore Technologies (ONT) platforms offers rapid turnaround times and low cost. Tracking low frequency intra-host variants provides important insigh...
The combination of the wealth of genomic and phenotypic datasets to the measurement of the circulating proteome enables a snapshot of real-time biology and important results for determining...
Recurrently emerging SARS-CoV-2 variants of concern (VOC) present increasingly sophisticated immune escape strategies that fuel global infection rates, as exemplified by the raging B.1.1.529...
Sex differences play an important role in development and progression of many diseases, and understanding how a disease differs between the sexes is essential for the advancement of preventi...
The human genome encodes 25,000 genes. But the biological complexity inherent in polygenic traits is a clear sign that the whole is greater than the sum of its parts. Genes, gene products, a...
The CYP2D6 enzyme metabolizes approximately 25% of commonly used pharmaceuticals and is of intense pharmacogenetic interest. Polymorphisms in CYP2D6 can alter an individual’s response...
Date: April 14, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CET) Across oncology applications, from research to molecular testing and pharmaceutical development, the ability to identify...
The vast structural diversity of proteins is responsible for their functional versatility, but also makes their expression and purification a demanding task. Tagging proteins with affinity t...
Learning Objectives: 1. Explain what is gene therapy is. 2. Explain what steps are involved for getting a gene therapy product to the clinic. 3. Discuss development and manufacturing process...
Date: April 06, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEDT) Digital PCR is a specialized tool for nucleic acid quantification which has applications in many research areas includin...
There is growing interest in the development of integrated continuous bioprocesses for the production of important biotherapeutics due to the potential for enhanced productivity, greater fle...
The design, optimization and troubleshooting of industrial bioprocesses are still largely based on empirical knowledge. Thus, the goal and motivation is to base these processes on a comprehe...
In the last decades, the upstream processing in biopharma industry has been revolutionized regarding the production of bioactive materials such as monoclonal antibodies, proteins and biother...
Biopharmaceuticals produced with mammalian cells are the key drivers for the medication of former untreatable diseases. The development of their production processes is still challenging bec...
Currently over 95 % of pharmaceutical products and transport fuels are derived from petroleum. Sustainable alternatives are critical to achieving net-zero emissions without detriment to qual...
The application of modeling tools to better understand and control bioprocess development and manufacturing has become a hot topic within the last few years. However, what do we actually nee...
Viral Vector gene therapy has been the focus of intense research driven by the safety profile and several clinical breakthroughs. As of March 2022, there are two viral vector gene therapies...
Date: April 05, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CET) Machine learning (ML) offers many benefits to researchers using a wide range of microscopy techniques. Easier workflows,...
Date: April 5, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Enteroviruses are non-enveloped positive-sense RNA viruses that cause diverse diseases...
Date: April 05, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEDT) Members of the cinnamic acid and stilbenoid chemical families are common intermediates in the production of important bi...
Date: March 31, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CET) Formalin-fixed paraffin-embedded (FFPE) tissues are the most widely used clinical sample types in histology and molecular...
Date: March 31, 2022 Time: 8:00am (PDT), 11:00am (EDT) The US horticulture industry suffers approximately $60 billion in losses each year as a result of...
Date: March 31, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Transient extreme ultraviolet (XUV) spectroscopy has become an increasingly popular tool in developing ultrafast science...